megaloblast

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megaloblast

 [meg´ah-lo-blast″]
a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.

meg·a·lo·blast

(meg'ă-lō-blast'),
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, 4) orthochromatic megaloblast.
See also: erythroblast.
[megalo- + G. blastos, + germ, sprout]

megaloblast

(mĕg′ə-lō-blăst′)
n.
An abnormally large nucleated red blood cell found especially in people having pernicious anemia or certain vitamin deficiencies.

meg′a·lo·blas′tic adj.

megaloblast

An enlarged erythroblast (erythrocyte precursor) with an enlarged nucleus, which arises in a background of vitamin B12 and/or folic acid deficiency and is characterised by asynchronous nucleocytoplasmic development, and manifest by delayed or incomplete nuclear maturation relative to cytoplasmic development; haemoglobinisation proceeds normally, while nuclear maturation slows as the maturation-dependent methyl precursors—usually provided by vitamin B12 and folic acid—are not present.

meg·a·lo·blast

(meg'ă-lō-blast)
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblast's four stages of development are: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, and 4) orthochromatic megaloblast.
See also: erythroblast
[megalo- + G. blastos, germ, sprout]

Megaloblast

A large erythroblast (a red marrow cell that synthesizes hemoglobin).
Mentioned in: Anemias
References in periodicals archive ?
THE diagnosis requires blood tests to look for megaloblasts in your blood and possibly in your bone marrow too, and to measure your levels of vitamin B12 and folic acid.
Bone marrow aspiration was hypercellular and contains RBC precursors called megaloblasts and hypersegmented megakaryocytes.
On investigating her blood picture she was also found to be anemic with megaloblasts on the peripheral smear.
Once the patients were selected, various hematological parameters including peripheral smear analysis for megaloblasts, macrocytes, hypersegmented neutrophils and RBC indices were carried out.
Megaloblasts are large cells with an increased nuclear/cytoplasmic ratio in which nuclear maturation is delayed, while cytoplasmic maturation is more advanced.