mediator complex(redirected from Mediator (coactivator))
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coactivation proteins involved in RNA polymerase transcription of DNA segments.
Farlex Partner Medical Dictionary © Farlex 2012
mediator complexA multimeric protein complex that is required for DNA-binding activation and regulated transcription of nearly all RNA polymerase II-dependent genes. The mediator complex (MC) serves as a bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. It is recruited to promoters by direct interactions with regulatory proteins, and it serves as a scaffold for assembling a functional pre-initiation complex with RNA polymerase II and general transcription factors.
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me·di·a·tor com·plex(mē'dē-ā-tōr kom'pleks)
Coactivation proteins involved in RNA polymerase transcription of DNA segments.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012