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meclizine hydrochloride (meclozine (UK))
Pharmacologic class: Anticholinergic
Therapeutic class: Antiemetic, antivertigo drug
Pregnancy risk category B
Decreases excitability of middle-ear labyrinth and depresses conduction in vestibular-cerebellar pathways
Tablets: 12.5 mg, 25 mg, 50 mg
Tablets (chewable): 25 mg
Indications and dosages
➣ Motion sickness
Adults: 25 to 50 mg P.O. 1 hour before travel. May repeat q 24 hours for duration of travel.
➣ Vertigo associated with diseases affecting the vestibular system
Adults: 25 to 100 mg P.O. daily in divided doses
• Hypersensitivity to drug
Use cautiously in:
• prostatic hypertrophy, stenosing peptic ulcer, bladder neck obstruction, pyloroduodenal obstruction, arrhythmias, angle-closure glaucoma, bronchial asthma
• pregnant or breastfeeding patients
• children (younger than age 12).
• Know that tablets may be chewed or swallowed whole.
CNS: drowsiness, fatigue, confusion, excitement, euphoria, nervousness, restlessness, insomnia, vertigo, visual and auditory hallucinations, seizures
CV: hypotension, palpitations, tachycardia
EENT: blurred vision, diplopia, tinnitus, dry nose, dry throat
GI: nausea, vomiting, diarrhea, constipation, dry mouth, anorexia
GU: difficulty urinating, urinary retention, urinary frequency
Skin: rash, urticaria
Drug-drug. Anticholinergics (including some antihistamines, antidepressants, atropine, haloperidol, phenothiazines): additive anticholinergic effects
Antihistamines, CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression
Drug-diagnostic tests. Skin tests using allergen extracts: false-negative results
Drug-behaviors. Alcohol use: additive CNS depression
• Discontinue drug, as ordered, at least 4 days before skin testing.
• Know that drug has anticholinergic effects.
• Tell patient to take as prescribed to minimize adverse effects.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to relieve dry mouth with hard candy or frequent sips of fluids.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.
meclizineAn antihistamine and anticholinergic used to manage motion sickness and vertigo caused by vestibular (inner ear) disease.
Allergic reaction, blurred vision, dry mouth, constipation, drowsiness.