mechlorethamine(redirected from Mechlorethamine hydrochloride)
an alkylating agent that produces interstrand and intrastrand cross-linkages in DNA with resultant miscoding, breakage, and failure of replication. Used primarily for the treatment of disseminated hodgkin's disease, especially in the MOPP treatment regimen, and for other lymphomas, including mycosis fungoides; administered intravenously as the hydrochloride salt. Called also nitrogen mustard.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
mechlorethamineA nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication.
Mechlorethamine was first developed as a chemical weapon.
A nitrogen mustard alkylating agent used for managing lymphomas; part of MOPP.
Nausea, vomiting, marrow suppression, skin vesiculation at injection site.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
mechlorethamineOncology An alkylating nitrogen mustard chemotherapeutic used for lymphomas Adverse effects GI Sx, BM suppression, skin vesiculation at injection site. See MOPP regimen.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
ni·tro·gen mus·tards(HN) (nī'trŏ-jĕn mŭs'tărdz)
A group of toxic chemicals developed for use as chemical-warfare agents.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012