IGF1

(redirected from Mechano growth factor)

IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.
References in periodicals archive ?
Mechano growth factor is a new string form of insulin-like-1 growth factor which is identified as IGF-1Ec in humans and IGF-1Eb in rodents.
studied MGF expression osteobalsts in response to mechanical overload and found that cellular proliferation and expression of mRNA insulin-like growth factor and Mechano growth factor in ostepbalsts were distinctively regulated in response to mechanical overload by mechanical signals at mRNA level.
There are two splice variants of the IGF-I gene expressed in skeletal muscle, IGF-I Ea and mechano growth factor (MGF), and these different IGF-I splice variants have been shown to have different functions.
Furthermore, we examined how the expression of androgen receptor, IGF-I Ea, mechano growth factor and myostatin mRNA is regulated in the skeletal muscles of male pigs after castration.
Hormones and related substances: Erythropoietin, human growth hormone, insulinlike growth factors, mechano growth factors, gonadotrophins, insulin, corticotrophins