mecamylamine


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Related to mecamylamine: Mecamylamine hydrochloride, Trimethaphan

mecamylamine

 [mek″ah-mil´ah-min]
a ganglionic blocking agent administered orally as the hydrochloride salt as an antihypertensive agent.

mecamylamine

/mec·a·myl·amine/ (mek″ah-mil´ah-min) a ganglionic blocking agent used in the form of the hydrochloride salt as an antihypertensive.

mecamylamine

A nonselective and noncompetitive ganglion-blocker once used to treat severe malignant hypertension. Mecamylamine binds ± 1/2 of nicotinic acetylcholine receptors; it may be effective in smoking cessation and can be used with nicotine replacement therapy (e.g., gum or patches). It may reduce tics and rage reactions in Tourette syndrome.

mecamylamine

Substance abuse A ganglion-blocker approved for HTN, possibly smoking cessation, to be used with nicotine replacement therapy–eg, gum or patches; it may ↓ tics and rage reactions in children with Tourette's syndrome. See Nicotine replacement therapy.
References in periodicals archive ?
Mecamylamine (a nicotine antagonist) for smoking cessation.
Lancaster T, Stead LF, Mecamylamine for smoking cessation.
Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol.
The study authors were also able to undo some harmful effects of nicotine in mice to some extent by treating them with the nicotine antagonist mecamylamine, a drug that blunts the action of nicotine.
Intensive Intervention for Toddlers with Autism; A Pilot study of Daytrana TM in Children with Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms; Minocycline to Treat Childhood Regressive Autism; Effectiveness of Atomoxetine in Treating Attention Deficit Hyperactivity Disorder Symptoms in Children and Adolescents with Autism; Comparing Parent-Implemented Interventions for Toddlers with Autism Spectrum Disorders and A Pilot Trial of Mecamylamine for the Treatment of Autism are just few clinical studies and intervention regimen on autism currently funded by the United States National Institute of Health (http://clinicaltrials.
VIENNA -- Mecamylamine, an old, rarely prescribed, truly obscure antihypertensive agent, may be favorably reincarnated as an antidepressant with a completely novel mechanism of action--and vastly greater potential use.
Furthermore, recent work on cuttlefish optic lobe slices (11) has shown that mecamylamine hydrochloride, a nicotinic receptor antagonist, blocks excitatory postsynaptic currents, which are due to spontaneously released ACh.
Presented data from the completed Phase II clinical trial of mecamylamine hydrochloride as an add-on therapy to citalopram hydrobromide, a treatment combination known as TRIDMAC(TM), at the 2007 Summer Meeting of the British Association for Psychopharmacology;
Induction of pulmonary cytochrome P4501A1 interactive effects of nicotine and mecamylamine.
Despite this, he added, "we now only use nicotine for special problems, because we've found something better: mecamylamine.