MDRD


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MDRD

A randomised trial with 2–4 years of planned followup that asked whether restriction of protein in the diet reduced the incidence of end-stage renal disease and death. While the early conclusion (1994) was that reduction was an insignificant, subsequent analysis (1999) concluded that the balance of evidence suggested a beneficial effect of protein restriction.
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Today, clinical laboratories customarily calculate eGFR using either the MDRD or CKD-EPI equation whenever a serum creatinine is obtained.
Abbreviations GFR --glomerular filtration rate cysC --cystatin C CKD --chronic kidney disease ESRD --end stage renal disease CV --cardiovascular DTPA --diethylenetriamine pentaacetate MDRD --Modicifaction of Diet in Renal Disease CKD-EPI --The Chronic Kidney Disease Epidemiology Collaboration [Cre.sub.equ] --formulas for calculating the GFR from serum concentrations of creatinine [CysC.sub.equ] --formulas for calculating the GFR from serum concentrations of cystatin C PENIA --particle enhanced nephelometric immunoassay PETIA --particle enhanced turbidimetric immunoassay PE --preeclamspia DM --diabetes mellitus DN --diabetic nephropathy CCIMT --intimo-medial complex of the common carotid artery Review article
Reasons to use the MDRD or CKD-EPI study equation to estimate GFR (5):
Caption: FIGURE 1: Scatter plots of the isotopic glomerular filtration rate (GFR) versus 1/creatinine, creatinine clearance, 1/cystatin C, Cockcroft-Gault formula, MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC.
* MDRD estimates GFR based on age, race, sex, and serum creatinine.
Using the 4-parameter MDRD equation, we compared the eGFR calculated from creatinine values obtained by various field methods between 2006 and 2011.
The two main formulas for the calculation of GFR are the Cockroft-Gault and MDRD (Modification of Diet in Renal Disease), although currently the most widely used is a modification of the simplified MDRD formula (sMDRD or simplified MDRD).
Estas variables se adoptan en las formulas de estimacion de la tasa de filtracion glomerular, como la de Cockcroft-Gault [3] y la Modification of Diet in Renal Disease (MDRD) [4], que son las mas utilizadas y mas fiables [5].
The MDRD study equation was developed in the USA using data from patients with CKD and there have been several versions of the equation.
Glomerular filtration rate was calculated using the Modification of Renal Diet (MDRD) equation.
Estimated glomerular filtration rate (eGFR) was calculated by two formulas; Cockcroft-Gault (CG) and Modification of Diet in Renal Disease Study (MDRD) (12, 13).
This equation is more accurate in determining kidney function than is the Modification of Diet in Renal Disease (MDRD) study equation, said Dr.