MCL1

(redirected from Mcl-1)

MCL1

A gene on chromosome 11q21 that encodes an anti-apoptotic protein of the Bcl-2 family.
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Chief Executive Officer of Tolero Pharmaceuticals, said, "Based on our improved understanding of the role that MCL-1 plays in the pathogenesis of AML, we are enlisting additional study centers to expand this important trial into Europe.
M2 EQUITYBITES-May 29, 2015-Beryllium starts development of MCL-1 platform
M2 PHARMA-May 29, 2015-Beryllium starts development of MCL-1 platform
The researchers have discovered that that they could exploit a small portion of the protein, called MCL-1, to make a molecular tool that hindered MCL-1's "pro-survival" action.
It is understood patients with a large number of the family's Mcl-1 proteins in their blood typically have a shorter lifespan than those without.
By using novel boronic acid chemistry our scientists have generated covalent inhibitors of Mcl-1, a notoriously difficult and key target in oncology
The team led by Dr Andrew Aplin, an associate professor of Cancer Biology at Jefferson Medical College of Thomas Jefferson University, has discovered a protein called Mcl-1 that plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis.