McCune-Albright disease

McCune-Albright disease

Albright syndrome, osteitis fibrosa cystica, polyostotic fibrous dysplasia An AD condition attributed to altered regulation of cAMP Clinical Precocious puberty, polyostotic–cystic fibrous dysplasia–spontaneous fractures at young age, café-au-lait spots of skin, ovarian cysts, endocrinopathy–eg, hyperthyroidism, hypophosphatemia and cyclical–4-6 wk-fluctuations of plasma estrogen; afflicted young girls have ↓ gonadotropins, ↓ response to LH-RH Lab ↑ Testosterone, ↑ alk phos Treatment Aromatase inhibitor testolactone. See Luteinizing hormone-releasing factor.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.