McArdle's disease


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McArdle’s disease

Glycogen storage disease V, see there.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

McArdle's disease

Glycogen storage disease V Metabolic disease An AR condition caused by muscle phosphorylase deficiency Clinical Exercise intolerance, premature fatigue, myalgia, and cramping
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

McArdle's disease

An autosomal recessive disorder of muscle carbohydrate metabolism in which glycogen breakdown is blocked because of non-functioning of the enzyme myophosphorylase. The effect is a considerable reduction in exercise capacity. Attempts at strenuous activity cause cramps, muscle injury, RHABDOMYOLYSIS and MYOGLOBINURIA. Ingestion of sucrose before exertion can markedly improve exercise capacity.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
A diagnostic cycle test for McArdle's disease. Ann Neurol 2003;54:539-42.
Randomized, placebo-controlled, double-blind pilot trial of ramipril in McArdle's disease. Muscle Nerve 2008;37:350-7.
Also called: Myophosphorylase deficiency, McArdle's disease, glycogenosis type 5