Mazzotti reaction

Maz·zot·ti test

a test for onchocerciasis using an oral test dose of diethylcarbamazine (50 or 100 mg), resulting in the appearance of an acute rash in 2-24 hours from death of microfilariae in the skin.
Synonym(s): Mazzotti reaction

Mazzotti reaction

A severe, potentially life-threatening allergic response that occurs within seven days of treatment of microfilariasis with diethylcarbamazepine in patients with onchocerciasis. The reaction correlates with the intensity of infection. 

Clinical findings
Intense pruritic rash, fever, malaise, lymphadenopathy, eosinophilia, arthralgia, tachycardia, hypotension, oedema, abdominal pain.


Luigi, Mexican parasitologist, 1900-1971.
Mazzotti reaction - Synonym(s): Mazzotti test
Mazzotti test - diagnostic test of onchocerciasis. Synonym(s): Mazzotti reaction

Mazzotti reaction

a skin reaction that occurs in humans when the microfilariae of Onchocerca volvulus in cutaneous sites are killed by the administration of diethylcarbamazine.