maximum tolerated dose

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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

maximum tolerated dose

dose that produces grade 3 (severe) or grade 4 (life-threatening) toxicity in 30% or fewer of the patients tested.

maximum tolerated dose

The highest drug dose that can be given without causing unacceptable adverse side effects in most recipients.

maximum tolerated dose

Abbreviation: MTD
The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects.
See also: dose
References in periodicals archive ?
The maximal tolerated dose was not reached and the recommended dose for part 2 of the study was determined.
This Phase I trial is designed to assess the safety and tolerance of the company's APG-2575 in patients with hematologic malignancies and confirm the maximal tolerated dose (MTD) or recommended Phase II dose (RP2D).
The Phase I, open label multicenter study aims at identifying the dose limiting toxicity and assess the maximal tolerated dose of Debio 1347 on the basis of the safety and tolerability of the product during a daily oral administration to patients with advanced solid tumors that have an alteration of the FGFR 1, 2 or 3 genes.
At the last dose level of curcumin, three dose-limiting toxicities were observed and two out of three patients at this dose level refused to continue treatment, leading us to define the maximal tolerated dose of curcumin at 8,000 mg/d.
Based upon the efficacy demonstrated in the recent study of photosensitive epilepsy patients, coupled with a favorable clinical safety profile, consistent pharmacokinetics and the lack of a maximal tolerated dose in all clinical studies to date, the company proposed, and the FDA approved, a study of up to two additional cohorts of photosensitive epilepsy patients at higher doses of ICA-105665.
When lifestyle changes and the maximal tolerated dose of metformin do not achieve or maintain glycemic goals, another medication should be added, either within 2-3 months of the initiation of therapy or at any time when the target [HbA.sub.1c] level is not achieved.
(TASE:BLRX), Israel's leading drug development company, today announced the initiation of a Phase II clinical trial on schizophrenic patients for the maximal tolerated dose determination of BL-1020.
This open-label, first-in-human Phase 1 dose escalation study will now evaluate the safety and maximal tolerated dose of the company's PRGN-3005 UltraCAR-T.
This first-in-human Phase 1 dose escalation study to evaluate the safety and maximal tolerated dose of PRGN-3006 UltraCAR-T will be conducted in collaboration with Moffitt Cancer Center.
Across all tumor types, 12 mg/kg was declared the maximal tolerated dose and 10 mg/kg declared the recommended Phase 2 dose.
The aim of the Phase I, open label multicentre study is to find the dose limiting toxicity and evaluate the maximal tolerated dose of Debio 1347, based on the safety and tolerability of the product during a daily oral administration to patients suffering from advanced solid tumours that have an alteration of the FGFR 1, 2 or 3 genes.
The objectives of the study are to evaluate the safety and maximal tolerated dose of escalating doses of SGX201, as well as the preliminary efficacy of SGX201 for prevention of signs and symptoms of acute radiation enteritis.

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