maturity onset diabetes of the young


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Related to maturity onset diabetes of the young: maturity onset diabetes of the young type 2

maturity onset diabetes of the young

Any of a number  of dominantly inherited, monogenic defects of insulin secretion occurring at any age (most commonly types 2 and 3). MODYs do not include any forms of type-2 diabetes, and comprise 1–2% of those initially diagnosed with diabetes. Given that MODYs are autosomal dominant, those with the faulty gene have a 95% chance of developing MODY during their lifetimes. Diagnosing MODY is important as some forms do not need insulin and may do well with oral hypoglycaemic agents, and because other family members can be identified and their treatment modified if appropriate.

MODY susceptibility genes:
• MODY type 1—HNF4A 
• MODY type 2—GCK     
• MODY type 3—HNF1A
• MODY type 4—PDX1
• MODY type 5—HNF1B
• MODY type 6—NEUROD1
• MODY type 7—KLF11
• MODY type 8—CEL
• MODY type 9—PAX4
• MODY type 10—INS
• MODY type 11—BLK
References in periodicals archive ?
Although type 1 diabetes is the most common type of diabetes in childhood, a variable increase in the prevalence of type 2 diabetes and maturity onset diabetes of the young has been reported by different multicenter studies depending on the ethnic background, the country of residence and the availability of genetic tests.
Evaluation of common variants in the six known maturity onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Maturity onset diabetes of the young (MODY) mainly affects individuals age 25 or younger and accounts for about 1 to 5 percent of all diabetes cases in the United States.
Identification of novel mutations in the HNF- 1a gene in south Indian patients with maturity onset diabetes of the young. Diabetes 2003; 52(Suppl 1):A254.
"When she was first diagnosed as a diabetic in 1996 she had been told she had MODY, which is Maturity Onset Diabetes of the Young.
Mr Rheinberg also explained that Miss McNicholas had been diagnosed as suffering type two diabetes or maturity onset diabetes of the young (MODY).
Mr Rheinberg said Miss McNicholas was diagnosed with type two diabetes or maturity onset diabetes of the young.
MATURITY Onset Diabetes of the Young: There is a virtual epidemic of mature onset diabetes in teenagers, attributed to the combination of fast food and a sedentary life leading to obesity.
Investigating maturity onset diabetes of the young. Clin Biochem Rev 2009;30:67-74.
In addition, mutation in the gene causes a severe form of neonatal diabetes as well as maturity onset diabetes of the young type 11 (MODY11) [22].
Madam, diabetes mellitus affects approximately 2.8% of the world\'s population, of which type 2 diabetes accounts for atleast 90% of the cases.1 MODY or maturity onset diabetes of the young is caused by mutation in autosomal dominant genes with early onset of hyperglycaemia and deficiency of insulin secretion.2 It differs from both type 1 and type 2 diabetes and is very rare in comparison to these two.
MODY (maturity onset diabetes of the young) is a monogenic diabetes mellitus caused by pancreatic beta cell dysfunction.

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