MMP8

(redirected from Matrix metalloproteinase-8)

MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Shapiro, "Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase," Journal of Immunology, vol.
Leppilahti et al., "Active matrix metalloproteinase-8: contributor to periodontitis and a missing link between genetics, dentistry, and medicine," in Pathogenesis of Periodontal Diseases, N.
Jones et al., "Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity," Circulation, vol.
Key words: matrix metalloproteinase-8, tissue inhibitor metalloproteinase-1, gene expression, removable orthodontic appliance
The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis [Electronic version].
Said et al., "Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance," Journal of Periodontal Research, vol.
Lundy, "Matrix metalloproteinase-8 activity in gingival crevicular fluid: development of a novel assay," Journal of Periodontal Research, 2016.
Chaiworapongsa et al., "Amniotic fluid matrix metalloproteinase-8 in preterm labor with intact membranes," American Journal of Obstetrics and Gynecology, vol.
Zhang et al., "An importantrole of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo," Cardiovascular Research.
Seven matrix metalloproteinases have been shown to be expressed under varying circumstances in articular cartilage--matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-8 (MMP-8), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-13 (MMP-13), and matrix metalloproteinase-14 (MMP-14).
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