MMP7

(redirected from Matrix metalloproteinase-7)

MMP7

A gene on chromosome 11q21-q22 that encodes matrix metalloproteinase 7, which degrades proteoglycans, fibronectin, elastin and casein and activates procollagenase. It is involved in breaking down the extracellular matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members as it lacks a conserved C-terminal protein domain.
 
Molecular pathology
Defects in MMP7 have been linked to arthritis and metastasis.
References in periodicals archive ?
Expression and activity levels of matrix metalloproteinase-7 and in situ localization of caseinolytic activity in colorectal cancer.
Matrix metalloproteinase-7 mediated cleveage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.
Expression of Matrix Metalloproteinase-7 on Cancer Cells and Tissue Endothelial Cells in Renal Cell Carcinoma: Prognostic Implications and Clinical Significance for Invasion and Metastasis.
Kanetake, "Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis," Clinical Cancer Research, vol.
Jung, "Plasma matrix metalloproteinase-7 as a metastatic marker and survival predictor in patients with renal cell carcinoma," Cancer Science, vol.
Liaw, "Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)," Journal of Biological Chemistry, vol.
Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.
Development of in situ zymography to localize active matrix metalloproteinase-7 (matrilysin-1).
Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas.
Matrix metalloproteinase-7 (MMP-7), a zinc- and calcium-dependent endopeptidase, is 1 of these 12 candidate proteins.
A multiplexed particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer.
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