MMP7

(redirected from Matrix metalloproteinase-7)

MMP7

A gene on chromosome 11q21-q22 that encodes matrix metalloproteinase 7, which degrades proteoglycans, fibronectin, elastin and casein and activates procollagenase. It is involved in breaking down the extracellular matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members as it lacks a conserved C-terminal protein domain.

Molecular pathology
Defects in MMP7 have been linked to arthritis and metastasis.

References in periodicals archive ?

Expression and activity levels of matrix metalloproteinase-7 and in situ localization of caseinolytic activity in colorectal cancer.

The Importance of Fecal and Plasma CEA, COX-2, MMP-7, and TIMP-1 in the Diagnosis of Colorectal Cancer

Matrix metalloproteinase-7 mediated cleveage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.

Expression of Matrix Metalloproteinase-7 on Cancer Cells and Tissue Endothelial Cells in Renal Cell Carcinoma: Prognostic Implications and Clinical Significance for Invasion and Metastasis.

Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma

Kanetake, "Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis," Clinical Cancer Research, vol.

Jung, "Plasma matrix metalloproteinase-7 as a metastatic marker and survival predictor in patients with renal cell carcinoma," Cancer Science, vol.

Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-[beta]/c-Fos-MMP-7 Pathways

Liaw, "Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)," Journal of Biological Chemistry, vol.

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.

Metalloproteinases involvement in liver tumoral pathology-an update

Matrix Metalloproteinase-7 activates MMP-8 but not MMP-13.

EXPRESSION OF MATRIX METALLOPROTEINASE-8 (MMP-8) GENE IN PATIENTS WITH FIXED ORTHODONTIC APPLIANCES

Development of in situ zymography to localize active matrix metalloproteinase-7 (matrilysin-1).

Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas.

Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis

Matrix metalloproteinase-7 (MMP-7), a zinc- and calcium-dependent endopeptidase, is 1 of these 12 candidate proteins.

Identification of pro-MMP-7 as a serum marker for renal cell carcinoma by use of proteomic analysis

A multiplexed particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer.

Matrix metalloproteinases in urinary system tumors. Part II - Matrix metalloproteinases in urinary bladder carcinoma