MMP3

(redirected from Matrix metalloproteinase-3)

MMP3

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 3, which degrades fibronectin, laminin, collagens III, IV, IX and X, and cartilage proteoglycans. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumour initiation.

Molecular pathology
Defects in MMP3 cause susceptibility to coronary heart disease type 6.

Mentioned in ?

coronary heart disease susceptibility type 6

References in periodicals archive ?

Caputo et al., "A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility," Clinical Cancer Research, vol.

A Matrix Metalloproteinase-1 Polymorphism, MMP1-1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients

Progesterone analogues similarly modulate endometrial matrix metalloproteinase-1 and matrix metalloproteinase-3 and their inhibitor in a model for long-term contraceptive effects.

Quantitative Analysis of Collagen Fibrillar Structure in Canine Uterus Exposed to Acetate of Medroxyprogesterone Using Second Harmonic Generation Microscopy/Analisis Cuantitativo de la Estructura de Fibras Colagenas en Utero Canino Expuesto a Acetato de Medroxiprogesterona Utilizando Generacion Microscopica de un Segundo Harmonico

Knofler, "Expression, Regulation and Functional Characterization of Matrix Metalloproteinase-3 of Human Trophoblast," Placenta, vol.

Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia

Son et al., "A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells," Journal of Neurochemistry, vol.

Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J Hepatol 2005; 42:520-527.

Metalloproteinases involvement in liver tumoral pathology-an update

Clinical disease activity in ankylosing spondylitis patients BASDAI <4 (n=20) BASDAI [greater Median than or equal to]4 (n=20) Median Matrix metalloproteinase-3 6.48 40.91 (ng/mL) Matrix metalloproteinase-9 5.35 5.94 (ng/mL) Tissue inhibitor of matrix 6.16 6.61 metalloproteinase-1 (ng/mL) Erythrocyte sedimentation 18 29 rate (mm/hr) C-reactive protein (mg/L) 5.5 7 P * Matrix metalloproteinase-3 <0.05 (ng/mL) Matrix metalloproteinase-9 <0.05 (ng/mL) Tissue inhibitor of matrix <0.05 metalloproteinase-1 (ng/mL) Erythrocyte sedimentation <0.05 rate (mm/hr) C-reactive protein (mg/L) <0.05 * Mann-Whitney U Test.

Association of matrix metalloproteinases and their tissue inhibitor with disease activity and development in spondyloarthropathy and inflammatory bowel disease

Matrix metalloproteinase-3 (MMP-3) is a zinc-dependent proteolytic enzyme that is converted to active MMP-3 through autocleavage; the active form remodels the extracellular matrix complex (EMC) in the basal lamina which forms part of the BBB [10].

MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease

Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1)and matrix metalloproteinase-7 (matrilysin).

Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis

Additionally, the cartilage degrading enzyme matrix metalloproteinase-3 was also evaluated in synovial fluid from OA patients.

Nutraceuticals research

Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes.

Two matrix metalloproteinases inhibitors from Ferula persica var. persica

Lower serum concentration of matrix metalloproteinase-3 (MMP-3) in the acute stage of myocardial infarction.

Increased plasma concentration of matrix metalloproteinase-7 in patients with coronary artery disease

Godon et al., "Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease," Clinical and Experimental Immunology, vol.

Matrix metalloproteinase-9: its interplay with angiogenic factors in inflammatory bowel diseases