MMP3

(redirected from Matrix metalloproteinase-3)

MMP3

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 3, which degrades fibronectin, laminin, collagens III, IV, IX and X, and cartilage proteoglycans. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumour initiation.
 
Molecular pathology
Defects in MMP3 cause susceptibility to coronary heart disease type 6.
References in periodicals archive ?
Caputo et al., "A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility," Clinical Cancer Research, vol.
Knofler, "Expression, Regulation and Functional Characterization of Matrix Metalloproteinase-3 of Human Trophoblast," Placenta, vol.
Son et al., "A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells," Journal of Neurochemistry, vol.
Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J Hepatol 2005; 42:520-527.
Clinical disease activity in ankylosing spondylitis patients BASDAI <4 (n=20) BASDAI [greater Median than or equal to]4 (n=20) Median Matrix metalloproteinase-3 6.48 40.91 (ng/mL) Matrix metalloproteinase-9 5.35 5.94 (ng/mL) Tissue inhibitor of matrix 6.16 6.61 metalloproteinase-1 (ng/mL) Erythrocyte sedimentation 18 29 rate (mm/hr) C-reactive protein (mg/L) 5.5 7 P * Matrix metalloproteinase-3 <0.05 (ng/mL) Matrix metalloproteinase-9 <0.05 (ng/mL) Tissue inhibitor of matrix <0.05 metalloproteinase-1 (ng/mL) Erythrocyte sedimentation <0.05 rate (mm/hr) C-reactive protein (mg/L) <0.05 * Mann-Whitney U Test.
Matrix metalloproteinase-3 (MMP-3) is a zinc-dependent proteolytic enzyme that is converted to active MMP-3 through autocleavage; the active form remodels the extracellular matrix complex (EMC) in the basal lamina which forms part of the BBB [10].
Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1)and matrix metalloproteinase-7 (matrilysin).
Additionally, the cartilage degrading enzyme matrix metalloproteinase-3 was also evaluated in synovial fluid from OA patients.
Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes.
Lower serum concentration of matrix metalloproteinase-3 (MMP-3) in the acute stage of myocardial infarction.
Godon et al., "Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease," Clinical and Experimental Immunology, vol.

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