MMP2

(redirected from Matrix metalloproteinase-2)

MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy.
Prognostic significance of matrix metalloproteinase-2,-8,-9, and-13 in oral tongue cancer.
Matrix metalloproteinase-2 expression in the left and right ventricles in response to different treatments
Zhang, "Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer," Prostate Cancer and Prostatic Diseases, vol.
Petronijevic et al., "Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer," Molecular and Cellular Biochemistry, vol.
Plasma levels of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 correlate with disease stage and survival in colorectal cancer patients.
Chong, "The amyloid-[beta] peptide suppresses transforming growth factor-[beta]1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells," Journal of Biological Chemistry, vol.
To examine protein expression of stromal cell-derived factor 1 (SDF-1), basic fibroblast growth factor (bFGF/FGF2) and matrix metalloproteinase-2 (MMP2) ELISAs (all DuoSet, R&D Systems, Minnesota, USA) were performed according to the manufacturer's instructions.
Watkins, "Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation," Journal of Biological Chemistry, vol.
Morning fasting venous blood samples were collected to measure MMP-1 (matrix metalloproteinase-1), MMP-2 (matrix metalloproteinase-2), TIMP-1 (tissue inhibitor of metalloproteinase-1), MMP-9 (matrix metallopeptidase-9), BDNF (brain-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), and VEGF (vascular endothelial growth factor).
Sahin, "Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase- 2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliationsyndrome," Clinical Ophthalmology, vol.
Matrix metalloproteinase-2 (MMP2), one of the most ubiquitous members of the matrix metalloproteinase family, cleaves collagen type IV of the extracellular matrix maintaining equilibrium between matrix synthesis and degradation, thus providing a critical role in the cell integrity and cell survival (Malemud, 2006).

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