MMP12

(redirected from Matrix metalloproteinase-12)

MMP12

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 12, which degrades soluble and insoluble elastin and thus is thought to be involved in tissue injury and remodelling.

Molecular pathology
MMP12 may play a key role in aneurysm formation and emphysema.
Mentioned in ?
References in periodicals archive ?
Sarabi et al., "Identification of matrix metalloproteinase-12 as a candidate molecule for prevention and treatment of cardiometabolic disease," Molecular Medicine, vol.
Kiechl et al., "Influence of matrix metalloproteinase-12 on fibrinogen level," Atherosclerosis, vol.
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.
Romano et al., "Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage," Annals of the Rheumatic Diseases, vol.
Baumann et al., "Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases," Cancer Research, vol.
5-HT does not enhance tumour cell proliferation but acts as a regulator of angiogenesis by reducing the expression of matrix metalloproteinase-12 (MMP-12) in tumourinfiltrating macrophages.
Katoh et al., "Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development," American Journal of Pathology, vol.

Full browser ?