MMP12

(redirected from Matrix metalloproteinase-12)

MMP12

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 12, which degrades soluble and insoluble elastin and thus is thought to be involved in tissue injury and remodelling.

Molecular pathology
MMP12 may play a key role in aneurysm formation and emphysema.

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References in periodicals archive ?

Sarabi et al., "Identification of matrix metalloproteinase-12 as a candidate molecule for prevention and treatment of cardiometabolic disease," Molecular Medicine, vol.

Kiechl et al., "Influence of matrix metalloproteinase-12 on fibrinogen level," Atherosclerosis, vol.

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.

Metalloproteinases involvement in liver tumoral pathology-an update

Romano et al., "Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage," Annals of the Rheumatic Diseases, vol.

Proinflammatory effects of diesel exhaust nanoparticles on scleroderma skin cells

Baumann et al., "Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases," Cancer Research, vol.

Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells

5-HT does not enhance tumour cell proliferation but acts as a regulator of angiogenesis by reducing the expression of matrix metalloproteinase-12 (MMP-12) in tumourinfiltrating macrophages.

Breast carcinoma progression and tumour vascular markers related to apoptotic mechanisms

Katoh et al., "Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development," American Journal of Pathology, vol.

The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas