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Related to matrix metalloproteinase: matrix metalloproteinase 12, matrix metalloproteinase 2, matrix metalloproteinase 9
endopeptidase subfamily that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
Farlex Partner Medical Dictionary © Farlex 2012
matrix metalloproteinaseA family of 25 zinc-dependent extracellular endopeptidases, which differ widely in substrate preferences (e.g., collagens, elastins, proteoglycans). MMPs are often present in disease and development; they are critical to tissue remodeling and expressed in certain malignancies, intimately linked to invasion and metastasis, an activity which is specifically blocked by tissue inhibitors of metalloproteinases (TIMPs). MMPs are also linked to tissue damage in interstitial lung disease, diffuse alveolar damage, and pulmonary lymphangioleiomyomatosis. MMPs are either secreted or membrane-bound (MT-MMPs) and anchored to the cell membrane by transmembrane and intracytoplasmic domains.
• Collagenases—digest triple-helical fibrillar collagens, major components of bone and cartilage. Members: MMP-1, MMP-8, MMP-13, MMP-18, MMP-14, MMP-2 (list differs from MESH, see there).
• Gelatinases—Digest type IV collagen and gelatin. Members: MMP-2, MMP-9.
• Stromelysins—Digest extracellular matrix proteins but not triple-helical collagens. Members: MMP-3, MMP-10, MMP-11.
• Membrane-type MMPs have a furin cleavage site (which is also seen in MMP-11, a stromelysin). Members: MMP-14 to MMP-17, MMP-24, MMP-25.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
A subfamily of endopeptidases that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012