matrix metalloproteinase

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matrix metalloproteinase

endopeptidase subfamily that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
Farlex Partner Medical Dictionary © Farlex 2012

matrix metalloproteinase

A family of 25 zinc-dependent extracellular endopeptidases, which differ widely in substrate preferences (e.g., collagens, elastins, proteoglycans). MMPs are often present in disease and development; they are critical to tissue remodeling and expressed in certain malignancies, intimately linked to invasion and metastasis, an activity which is specifically blocked by tissue inhibitors of metalloproteinases (TIMPs). MMPs are also linked to tissue damage in interstitial lung disease, diffuse alveolar damage, and pulmonary lymphangioleiomyomatosis. MMPs are either secreted or membrane-bound (MT-MMPs) and anchored to the cell membrane by transmembrane and intracytoplasmic domains.

Matrix metalloproteinases
• Collagenases—digest triple-helical fibrillar collagens, major components of bone and cartilage. Members: MMP-1, MMP-8, MMP-13, MMP-18, MMP-14, MMP-2 (list differs from MESH, see there).

• Gelatinases—Digest type IV collagen and gelatin. Members: MMP-2, MMP-9.

• Stromelysins—Digest extracellular matrix proteins but not triple-helical collagens. Members: MMP-3, MMP-10, MMP-11.

• Membrane-type MMPs have a furin cleavage site (which is also seen in MMP-11, a stromelysin). Members: MMP-14 to MMP-17, MMP-24, MMP-25.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ma·trix me·tal·lo·pro·tein·ase

(mā'triksmĕ-tal'ō-prō'tē-nās)
A subfamily of endopeptidases that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Caption: Figure 2: The effect of HXJD on the expression of genes associated with cytokine signalling and matrix metalloprotease expression.
"Patients who reached success at 12 weeks were those who started with lower baseline levels of matrix metalloprotease, or lower or intermediate baseline levels of serine protease," Dr.
As stated, a number of disease states involve overexpression of matrix metalloproteases, and there exist diseases in which mutations result in overexpression of MMP-13 and premature development of osteoarthritis.
It has also been shown that membrane type 1 matrix metalloproteases are modifying the laminin-rich basal membrane, playing thus a role in transformation of prostate intraepithelial neoplasm into invasive cancer through their capacity to degrade laminin [39, 51,52].
Yuchuan et al., "A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8(Methoxycarbonylamino)dibenzo[fi,d]furan-3-sulfonamido) -3-methylbutanoic acid (MMP408)," Journal of Medicinal Chemistry, vol.
Guzman-Morales et al., "Matrix metalloproteases from chondrocytes generate an antiangiogenic 16 kDa prolactin," Journal of Cell Science, vol.
A role for elastolytic activities has been put forward by some authors [3-5], who consider the disease as a possible consequence of an abnormal extracellular matrix degradation, caused by a defect of elastin maturation because of a decrease of lysyl oxidase-like 2 (LOX2) activity [6] and/or by an increase of serine- or matrix metalloprotease activities (MMPs).
MSCs can also produce matrix metalloprotease (MMP) during cell proliferation and differentiation, which may affect the mechanical properties of the scaffolds.
Mechanical stress induces matrix metalloprotease expression in the skin.
[1] Nonstandard abbreviations: ECM, extracellular matrix; uPA, urokinase plasminogen activator; MMP, matrix metalloprotease; and LOE-1, level 1 evidence.
Of these, tyrosinase, superoxide dismutase, calalase, matrix metalloprotease, and glutathione peroxidase are most important from skin anti-aging point of view.

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