Twenty years of enamel matrix derivative: the past, the present and the future.

Human periodontal fibroblast response to enamel matrix derivative, amelogenin, and platelet-derived growth factor-BB.

Use of enamel matrix derivative (EMD) for treatment of combined apicomarginal lesions in apical surgery: A retrospective analysis.

15 1 year 87% No significant 2015 (23) 15 80% difference von Arx & 17 1-5 years 82.4% NA Bosshardt (present study) ABBM=anorganic bovine bone mineral; EMD=enamel matrix derivative; NA=not applicable; PRF=platelet-rich fibrin; PRP=platelet-rich plasma

Nunn, "Prospective assessment of the use of enamel matrix derivative with minimally invasive surgery: 6-year results," Journal of Periodontology, vol.

Tonetti, "A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity," Journal of Clinical Periodontology, vol.

performed SCTG combined with double papilla flap or a repositioned flap,3,4 while Andrade performed CAF with enamel matrix derivative.32 Pandey and Mehta performed CAF combined with free rotated papilla autograft.31

Number of sites exhibiting complete root coverage: Two split-mouth studies3,4 employing SCGT and one parallel study32 combining CAF with enamel matrix derivative reported the results of complete root coverage.

Mellonig, "Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series," Journal of Periodontology, vol.

Dard, "Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning," Tissue Engineering B: Reviews, vol.

In the present study, the commercially available product Emdogain, which consists of enamel

matrix derivative and the vehicle propylene glycol alginate, was used.

Dard, "Enamel

matrix derivative: a review of cellular effects in vitro and model of molecular arrangement and functioning," Tissue Engineering B, vol.