ST14

(redirected from Matriptase)

ST14

A gene on chromosome 11q24-q25 that encodes matriptase, a type-II transmembrane serine protease which degrades extracellular matrix and is thought to play a role in breast cancer invasion and metastasis.

Molecular pathology
Defects in ST14 cause ichthyosis with hypotrichosis, autosomal recessive.
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References in periodicals archive ?
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
Akiyama et al., "Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis," Cancer Science, vol.
Human Adipose Mesenchymal Stem Cells Show More Efficient Angiogenesis Promotion on Endothelial Colony-Forming Cells than Umbilical Cord and Endometrium
Additional evidence for the current consensus of protease-protease inhibitor deregulation in macrophages from patients with COPD was provided by the fact that human patients with the most common a1-antitrypsin mutation have greater proteolytic activity partially due to higher expression levels of the membrane-bound serine protease matriptase [196].
Dysregulated Functions of Lung Macrophage Populations in COPD
Jin, "Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters," Histopathology, vol.
CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis
IL-4/13 significantly increased, whereas IFN-a significantly decreased the expression of kallikreins 5 and 7, matriptase and channel-activating serine protease 1.
T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes
Cell surface proteolysis is an important process in development and maintenance of healthy epithelial homeostasis via proper functioning of type II transmembrane serine protease, matriptase. The regulation of intestinal barrier integrity via matriptase modulation is one of the key pillars in the normal gut physiology.
Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status
(100,115,117,118) Other proteases that have been shown to contribute to HNSCC invasion include MMP-10, (66) MMP-13, (80) matriptase, (119) fibroblast activation protein, (120) and uPA/ uPAR, (117,121-124) as well as the glycosidase heparanase.
Mechanisms of Invasion in Head and Neck Cancer
Fremont, CA, February 13, 2015 --(PR.com)-- AnaSpec is pleased to announce the launch of the first commercially available kit for measuring the activity of Matriptase, a protease implicated in carcinogenesis.
AnaSpec Launches Industry's First Assay for Measuring Matriptase Activity
Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis.
New study reveals four nutrients that lower PSA and slow cancer progression
Co- localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol.
Oral manifestations of lamellar ichthyosis: A rare case report and review
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk.
A dimeric high-molecular-weight chymotrypsin inhibitor with antitumor and HIV-1 reverse transcriptase inhibitory activities from seeds of Acacia confusa
Curcumin treatment significantly resulted in reduced matrix metalloproteinase 9 activity and downregulation of cellular matriptase, a membrane-anchored serine protease with oncogenic roles in tumor formation and invasion.
Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis

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