maternal age effect

(redirected from Maternal age)

maternal age effect

The adverse impact that increased age in the mother has on obstetric events: increased complication rate; increased foetal defects, due to various effects of ageing on the uterus and eggs); and increased frequency of non-disjunctional chromosomal events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15.

Maternal age and chromosome defects 
[Age—Frequency of trisomy 21 (Down syndrom)—Frequency of other defects] 
▪ <20—1/1900—1/526
▪ 25—1/1200—1/476
▪ 30—1/885—1/384
▪ 35—1/365—1/178
▪ 40—1/109—1/63
▪ 45—1/32—1/18
▪ 49—1/12—1/7

maternal age effect

The adverse impact that ↑ age has on obstetric events: ↑ complication rate, ↑ fetal defects–possibly due to an unknown effect of aging on the uterus and eggs; ↑ frequency of non-disjunctional events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15. See Elderly primigravida. Cf Paternal age.
Maternal age & chromosome defects  
 Age Trisomy 21 Others
 <20 1/1900 1/526
 25 1/1200 1/476
 30 1/885 1/384
 35 1/365 1/178
  40 1/109 1/63
 45 1/32 1/18
 49 1/12 1/7
Mentioned in ?
References in periodicals archive ?
While numerous studies have investigated the risk of perinatal outcomes with advancing maternal age, the primary objective of a recent study by Lisonkova and colleagues was to examine the association between advancing maternal age and severe maternal morbidities and mortality.
The majority of included studies adjusted for maternal age, sex of child, mother's parity, and some measure of socioeconomic status (Table 3).
Here, we present a pregnant women who underwent amniocentesis (AFS) for advanced maternal age and diagnosed as inv(12) in prenatal karyotype analysis.
Table 2 shows that extremes of the maternal age affect the birth weight of babies.
Due to poor antenatal care and advanced maternal age, pregnancy and delivery in grandmultipara are at higher risk2.
But after adjustment for maternal age and other antirheumatic drugs, the risk was not statistically significant.
Background and Objective: Maternal age is an important determinant of pregnancy outcome.
The mean maternal age at birth of the affected children was 36.27 [+ or -] 7.59 years.
'Our results show that the proportion of operative deliveries increased substantially with maternal age in a low-risk, first-time mother cohort.'
Rates of induction at 38 weeks of gestation declined in 36 states and Washington, D.C., and among all maternal age groups younger than 40 years old.
Identifying high-risk women based on maternal age has poor detection rate.
With the British and American Colleges of Obstetricians and Gynaecologists recommending that all women, regardless of maternal age, be offered prenatal assessment for aneuploidy, the UAE needs to benchmark this to ensure women are better informed and able to make their own choices about their pregnancy.

Full browser ?