maspin


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maspin

A 42-kD tumour suppressor protein of the serpin superfamily, encoded by SERPINB5 on chromosome 18q21.3. Despite its name, maspin (mammary serine protease inhibitor) has no serine protease inhibitory activity.

Normal expression
Various epithelial cells.

Abnormal expression
Downregulated in breast, prostate and colorectal carcinomas; upregulated in pancreatic, gastric and ovarian cancers.
References in periodicals archive ?
Expression and clinical significance of microRNA-21, maspin and vascular endothelial growth factor-C in bladder cancer.
The natural tumor suppressor protein maspin and potential application in nonsmall cell lung cancer.
(9) had been incompletely characterised in terms of p63, maspin, E- and P-cadherin expression, it was possible that the lesion was a low-grade spindle cell metaplastic breast carcinoma (SpCMBC) (24).
Nuclear cytokine-activated IKK[alpha] controls prostate cancer metastasis by repressing maspin. Nature 2007; 446: 690-694, doi: 10.1038/nature05656.
Arbiser, "Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma," Journal of the American Academy of Dermatology, vol.
For example, using a dCas9-SAM-VPR complex, researchers reactivated a heavily methylated tumor suppressor gene, Maspin, in lung cancer cells both transcriptionally and translationally, which limited cancer cell growth and apoptosis [73].
Detection of the placental epigenetic signature of the maspin gene in maternal plasma.
(3) To our knowledge, S100P, insulin-like growth factor 2 messenger RNA-binding protein-3 (IMP3), maspin, von HippelLindau gene product (pVHL), SMAD4, CK17, and MUC5AC appear to be better investigated (Table 6), and will be briefly discussed here.
Fox et al., "Decreased levels of mir-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice," Gastroenterology, vol.
These effects are probably associated with multiple tumor suppressor genes' concurrent downregulation throughout the various stages of tumor progression, including PDCD4, TPM1, maspin, and PTEN [20, 45].