Marine-Lenhart syndrome

Marine-Lenhart syndrome

toxic multinodular goiter.

Ma·rine-Len·hart syn·drome

(mah'rēn-len'hahrt sin'drōm)
Toxic multinodular goiter.
References in periodicals archive ?
The coexistence of nodules can occur in up to 35% of patients and in 0.8-2.7% of cases these nodules are functioning adenomas, a combination that has been termed Marine-Lenhart syndrome [2-5].
The coexistence of Graves' disease and functioning nodules is called Marine-Lenhart syndrome, but the criteria for its diagnosis are not well established.
In order to reconcile the above discrepancies in the definition of the Marine-Lenhart syndrome, we propose the following criteria for the diagnosis and classification of patients with Graves' disease and functioning nodules: (1) thyroid function tests consistent with hyperthyroidism inclusive of serological testing for Graves' disease (TRAb/TSI); (2) increased radioiodine uptake and the presence of "cool" or "hot" nodules; thyroid nodularity should be supported by ultrasonography [24]; (3) thyroid nodule biopsy revealing a hyperplastic lesion or follicular adenoma, although, in the latter case, diagnostic surgery may be required to rule out a follicular carcinoma.
Charkes, "Graves' disease with functioning nodules (Marine-Lenhart syndrome).," Journal of Nuclear Medicine, vol.
Sharma, "Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature," Journal of pediatric endocrinology metabolism : JPEM, vol.
Ozel et al., "A Rare Presentation of Autonomously Functioning Papillary Thyroid Cancer: Malignancy in Marine-Lenhart Syndrome Nodule," Case Reports in Surgery, vol.
Tosun, "Marine-lenhart syndrome with papillary thyroid carcinoma," Journal of Research in Medical Sciences, vol.
Komatsu, "A Case of Marine-Lenhart Syndrome with a Negative TSH Receptor Antibody Titer Successfully Treated with a Fixed, Low Dose of [I.sup.131]," Case Reports in Endocrinology, vol.
Certo et al., "An uncommon case of Marine-Lenhart syndrome," Arquivos Brasileiros de Endocrinologia & Metabologia, vol.
Chungath, "Hybrid SPECT/CT evaluation of Marine-Lenhart syndrome," Clinical Nuclear Medicine, vol.
Dhatariya, "The oldest case of Marine-Lenhart syndrome?" JRSM Short Reports, vol.
Moralidis, "Marine-Lenhart syndrome and radioiodine-131 treatment," Thyroid, vol.