margatoxin


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margatoxin

A peptide toxin in the venom of the Central American bark scorpion (Centruroides margaritatus) which selectively inhibits Kv1.3 voltage-dependant potassium channels. It blocks mitogen-induced proliferation and IL-2 and IFN-gamma secretion. It is 100-fold more effective at preventing the most common cause of bypass graft failure—neointimal hyperplasia, a natural response of blood vessels to injury—than any other known compound, a finding which may have future therapeutic potential.
References in periodicals archive ?
Margatoxin, from the venom of the Central American bark scorpion, proved effective in preventing a complication.
To date, in vivo immunosuppressive treatments that use nonspecific (4-AP and quinidine) and various highly selective [K.sub.v] channel blockers (margatoxin, correolide, kaliotoxin, ShK, and Sh-Dap22) have been restricted to miniswine [16-17] and rodent experimental allergic encephalomyelitis (EAE) [18-20] animal models for MS.