Marek's disease

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Marek’s disease

A highly contagious, viral-induced (caused by Gallid herpesvirus 2) neoplastic process affecting poultry.

Clinical findings
• Classical Marek's disease—causes asymmetric paralysis of one or more limbs and, with vagus nerve involvement, difficulty in breathing or dilation of the crop.
• Acute Marek's disease—an epidemic illness that affects uninfected or unvaccinated flocks, characterised by depression, paralysis and death in a large number of birds (up to 80% mortality).
• Cutaneous Marek’s disease— causes round, firm lesions at the feather follicles.
• Other findings—immunosuppression, atherosclerosis, ocular lymphomatosis.
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References in periodicals archive ?
Marek Disease Virus: molecular approach to the virus and host immune response
(10,11) Severe leukocytosis in birds is often associated with diseases such as aspergillosis, avian mycobacteriosis, salmonellosis, chlamydiosis, and sepsis, (12) but herpesviruses (ie, Marek disease) and retroviruses (ie, avian leukosis virus, reticuloendotheliosis virus) can specifically cause a lymphocytic leukocytosis in chickens.
Lesions resembling human atheromata developed in pathogen-free chickens infected with Marek disease virus, an avian herpesvirus; immunization with turkey herpesvirus was protective.