Marchiafava-Bignami disease


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Mar·chi·a·fa·va-Big·na·mi dis·ease

(mahr-kē-ă-fah'vah bēn-yah'mē),
a disorder recognized primarily by its pathologic features, consisting of demyelination of the corpus callosum and cortical laminar necrosis involving the frontal and temporal lobes. Occurs predominantly in those with chronic alcoholism, particularly wine drinkers.

Marchiafava-Bignami disease

A condition that occurs in chronic alcoholics, clinically characterised by progressive neurological disease and histologically characterised by corpus callosum demyelination, necrosis and atrophy.

Mar·chi·a·fa·va-Big·na·mi dis·ease

(mahr-kē-ă-făh'vah-bēn'yah'mē di-zēz')
A disorder characterized by demyelination of the corpus callosum and cortical laminar necrosis involving the frontal and temporal lobes. Occurs predominantly in chronic alcoholics, particularly wine drinkers.

Bignami,

Amico, Italian physician, 1862-1929.
Marchiafava-Bignami disease - see under Marchiafava

Marchiafava,

Ettore, Italian pathologist, 1847-1935.
Marchiafava syndrome - Synonym(s): Marchiafava-Bignami syndrome
Marchiafava-Bignami disease - a disorder consisting of demyelination of the corpus callosum and cortical laminar necrosis involving the frontal and temporal lobes. Synonym(s): Marchiafava syndrome
Marchiafava-Micheli anemia - Synonym(s): Marchiafava-Micheli syndrome
Marchiafava-Micheli syndrome - an infrequent disorder with insidious onset and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria, pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly. Synonym(s): Marchiafava-Micheli anemia; paroxysmal nocturnal hemoglobinuria

Mar·chi·a·fa·va-Big·na·mi dis·ease

(mahr-kē-ă-fah'vah-bēn-yah'mē di-zēz')
Disorder recognized primarily by its pathologic features, consisting of demyelination of corpus callosum and cortical laminar necrosis involving frontal and temporal lobes.
References in periodicals archive ?
To evaluate alcohol's central nervous system effects, researchers distinguish "uncomplicated alcoholism" (i.e., alcohol use disorder [AUD]) from the various clinically diagnosable consequences of chronic alcohol consumption, including Wernicke's encephalopathy (WE), Korsakoff's syndrome (KS), hepatic encephalopathy (HE), central pontine myelinolysis (CPM), alcoholic cerebellar degeneration (ACD), alcohol-related dementia (ARD), and Marchiafava-Bignami disease (MBD).
Marchiafava-Bignami disease: Role of neuroimaging in the diagnosis and management of acute disease.
Marchiafava-Bignami disease: A rare entity with a poor outcome.
[3] There are no characteristic clinical presentations of Marchiafava-Bignami disease. Clinical clues for the disease are reduced consciousness, psychotic and emotional symptoms, depression and apathy, aggression, seizures, hemiparesis, ataxia, apraxia and frequently leading to coma and death.
Marchiafava-Bignami disease may present in various clinical forms [5.6].
In contradistinction to Marchiafava-Bignami disease, SCD affects the posterior columns of the spinal cord.
Differential considerations, which usually lead to persistent abnormalities, are diffuse axonal injury, multiple sclerosis, lymphoma and-more rarely--extra-pontine myelinolysis, Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome (PRES).(1), (2)
Structural MRI studies have shown that subcortical and brainstem structures known to be affected in severe neurological syndromes such as Marchiafava-Bignami disease, 5 central pontine myelinolysis, alcoholic cerebellar degeneration, and Korsakoff's syndrome, which are all associated with excessive alcohol consumption or associated nutritional deficiency, also are affected in patients with uncomplicated alcoholism, albeit to a lesser degree (Sullivan and Pfefferbaum 2009).
(5) Marchiafava-Bignami disease is a progressive neurological disease characterized by degeneration of the corpus callosum.
Marchiafava-Bignami disease: A rare disorder that affects middle-aged alcoholics who consume large quantities of red wine.