Marburg virus disease


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Related to Marburg virus disease: Marburg hemorrhagic fever, African hemorrhagic fever

Marburg virus disease

 [mahr´boork]
a severe, often fatal, type of hemorrhagic fever first reported in Marburg, Germany, among laboratory workers exposed to African green monkeys.

Mar·burg dis·ease

infection with an unusual rhabdovirus composed of RNA and lipid, tentatively assigned to the family of Filoviridae. Virus is "pantropic" and affects most organ systems. The disease, characterized by a prominent rash and hemorrhages in many organs, is often fatal. First seen among laboratory workers in Marburg, Germany, exposed to African green monkeys. Some interhuman spread has been observed. Attempts to isolate virus should be done only in high-security laboratories.
A rare viral haemorrhagic fever which occurs in miniclusters in Europe and Africa following direct contact with monkey tissue, blood or human serum infected with the Marburg virus.
Incubation 5-9 days; otherwise like Argentine or Bolivian hemorrhagic fever—headaches, fever, diarrhoea, myalgias, rash, pharyngitis, thrombocytopenia, leukopenia, hemorrhage, renal failure
Mortality 7 of the 31 original Marburg cohort died

Mar·burg dis·ease

(mahr'bĕrg di-zēz')
Infection caused by a virus of the order Mononegavirales and the family Filoviridae and of the genus Marburg. The virus is "pantropic" and affects most organ systems. The disease is characterized by a prominent rash and hemorrhages in many organs and is often fatal. It was first seen in Marburg, Germany in 1967, among laboratory workers exposed to African green monkeys. Some person-to-person spread has been observed. Attempts to isolate the virus should be done only in high-security laboratories.
See also: Marburg virus
Synonym(s): Marburg virus disease.
References in periodicals archive ?
Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences.
In addition, the company's goal is to file investigational new drug (IND) applications for intravenous (i.v.) and intramuscular (i.m.) BCX4430 for the treatment of Marburg virus disease, and to conduct an initial Phase 1 human clinical trial.
Reports of Marburg virus disease are rare, and its occurrence has been limited to countries in sub-Saharan Africa.
A cluster of Marburg virus disease involving an infant.
Case definition recommendations for Ebola or Marburg Virus Diseases. [online] [cited 2014 Oct 25]; Available from: URL : http://who.int/csr/resources/publications/ebola/ebola- case-definition-contact-en.pdf.
Case definition recommendations for Ebola or Marburg virus diseases. Available at http://www.who.int/csr/resources/ publications/ebola/ebola-case-definition-contact-en.pdf.
Case definition recommendations for Ebola or Marburg virus diseases. Available at http://www.who.int/csr/resources/publications/ebola/ebola-case-definition-contact-en.pdf.