mannan-binding lectin

(redirected from Mannose-binding lectins)

mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Zanetta, "Mannose-binding lectins in cerebrum development," Progress in Molecular and Subcellular Biology, vol.
Isoforms of mannose-binding lectins purified from Cratylia mollis leguminous seeds, Cramoll 1 and Cramoll 1,4, demonstrated high potential to stimulate human T lymphocyte mitogen in vitro [77].
The closely related homomeric and heterodimeric mannose-binding lectins from garlic are encoded by one-domain and two-domain lectin genes, respectively.
Structure-function relationship of monocot mannose-binding lectins. Plant Physiol., 112: 15311540
Mannose-binding lectins isolated from the serum of Salmo salar have been reported to act as opsonising agents against Aeromonas salmonicida (Ottinger et al., 1999).
A simple micro-method for determining precise oligosaccharidic specificity of mannose-binding lectins. Glycobiology 19: 1417-1426.
Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities.
Recent advances in biochemical study, molecular cloning, and structural analysis of lectins have categorized them into seven families of structurally and evolutionarily related pro teins, namely the legume lectins, the monocot mannose-binding lectins (also termed GNA-related lectins), the chitin-binding lectins, type II ribosome inactivating proteins (RIPs II), the jacalin related lectins as well as the Cucurbitaceae phloem lectins (Van Damme et al.
The term 'monocot mannose-binding lectins' refers to a superfamily of strictly mannose-binding specific lectins that are widespread among monotyledonous plants and possess a broad range of biological activities, including anti-tumor, anti-HIV, antiviral and anti-fungal activities (Li et al., 2009; Damodaran et al., 2008; Van Damme et al., 1998).
In the present study, three typical monocot mannose-binding lectins (e.g., Polygonatum cyrtonema lectin [PCL], Ophiopogon japonicus lectin [OJL] and Liparis noversa lectin [LNL]), were reported to possess a similar tertiary structure with three mannose-binding sites and a close phylogenetic relationship.

Full browser ?