mannan-binding lectin

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mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
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References in periodicals archive ?
(11.) Garred P, Larsen F, Madsen HO, Koch C: Mannose-binding lectin deficiency--revisited.
Ozkinay, "Does mannose-binding lectin have a role in adult turkish patients with nasal polyposis?" Otolaryngology--Head and Neck Surgery, vol.
Caption: FIGURE 1: The relationship between different pathophysiological processes implicated in AP and susceptibility genes is concluded as follows: PRSS1: cationic trypsinogen; SPINK1: serine protease inhibitor Kazal type 1; CTRC: chymotrypsin C; ACE: angiotensin- converting enzyme; MIF: migration inhibitory factor; iNOS: inducible nitric oxide synthase; COX-2: cyclooxygenases 2; MYO9B: myosin IXB; TLRs: toll-like receptors; MCP-1: monocyte chemoattractant protein-1; HBDs: human [beta]-defensin 2; MBL2: mannose-binding lectin 2; TNF-[alpha]: tumor necrosis factor-[alpha]; IL-10: interleukin 10; TLR4: toll-like receptor 4.
Klein, "Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study," The Lancet, vol.
Saraheimo et al., "Association between mannose-binding lectin, high-sensitivity C-reactive protein and the progression of diabetic nephropathy in type 1 diabetes," Diabetologia, vol.
Mannose-binding lectin (MBL) replacement therapy was reported as a healing strategy of a radiation-induced chronic ulcer [125].
Dietz et al., "Mannose-binding lectin variant associated with severe malaria in young African children," Microbes and Infection, vol.
Researchers from Washington University, Walter Reed Army Institute of Research and the University of Copenhagen, Denmark, report a new finding that a part of the immune system called mannose-binding lectin (MBL) is involved in targeting dengue viruses for destruction.

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