mannan-binding lectin

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mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
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References in periodicals archive ?
Genotyping of mannose binding lectin was involved three miss-sense variations in exon 1 (R52C, G54D and G57E).
Midilli et al., "Evidence of an association between mannose binding lectin codon 54 polymorphism and adenoidectomy and/or tonsillectomy in children," International Journal of Pediatric Otorhinolaryngology, vol.
Besmond, "The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis," Journal of Medical Genetics, vol.
Castaldo, "Biological role of mannose binding lectin: from newborns to centenarians," Clinica Chimica Acta, vol.
Alkady, "Mannose binding lectin gene polymorphism and preclinical carotid atherosclerosis in patients with systemic lupus erythematosus," The Egyptian Journal of immunology/Egyptian Association of Immunologists, vol.
The C-type lectin family includes the mannose receptor, mannose binding lectin, and ficolins and are active in immune-system functions such as pathogen recognition.
Studies related to immune function have focused on a number of candidate genes such as, mannose binding lectin (MBL2), intedeukin 1-alpha, (ILIA), storkhead box 1 (STOX1), and cytoxic T lymphocyte associated 4 (CTLA4) with variable results (3, 4).
A haemolytic assay was developed based on the principle of yeast induced lysis of bystander chicken erythrocytes for the estimation of functional mannose binding lectin levels in human serum (15).
Baldas et al., "Evidence of a correlation between mannose binding lectin and celiac disease: a model for other autoimmune diseases," Journal of Molecular Medicine, vol.