mannan-binding lectin


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mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
References in periodicals archive ?
Veenhoven et al., "Functional polymorphisms in the mannan-binding lectin 2 gene: Effect on MBL levels and otitis media," The Journal of Allergy and Clinical Immunology, vol.
Holmich, "Mannan-binding lectin and healing of a radiation-induced chronic ulcer--a case report on mannan-binding lectin replacement therapy," Journal of Plastic, Reconstructive and Aesthetic Surgery, vol.
Knudsen et al., "Elevated levels of mannan-binding lectin in patients with type 1 diabetes," The Journal of Clinical Endocrinology & Metabolism, vol.
Kilpatrick, "Mannan-binding lectin: clinical significance and applications," Biochimica et Biophysica Acta, vol.
A growing body of evidence links the complement system, in particular mannan-binding lectin (MBL) and the lectin partway, to this pathophysiological process.
Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America.
Adult mallard ducks (Arias platyrhynchos) were orally dosed with bunker C fuel oil for 5 days, and 5 different inflammatory markers (haptoglobin, mannan-binding lectin, ceruloplasmin, unsaturated iron-binding capacity, and plasma iron) were measured in blood plasma before and 8, 24, 48, and 72 hours after exposure.
The lectin pathway is initiated when MBL (mannan-binding lectin) or ficolins (L-H-M) bind to patterns of carbohydrates [1-3] or acetyl groups on the surface of protozoan, virus, fungi, or bacteria [4].
Different molecular events results in low protein levels of mannan-binding lectin in populations from Southeast Africa and South America.
Detection and characterization of a mannan-binding lectin from mosquito, Anopheles stephensi (Liston).