Coffey, "Development of mammary hyperplasia
and neoplasia in MMTV-TGF[alpha] transgenic mice," Cell, vol.
Mammary hyperplasia is diagnosed commonly in company animals, but rarely in herbivores (HONG, 1994; MISDORP, 2002).
This case of bovine mammary hyperplasia appears to have good prognosis because there was no recurrence of the mammary lesions for at least 1 year after surgical excision, as observed in the bubaline mammary fibroadenomatoid hyperplasia (SANT'ANA et al., 2014).
Wahler et al., "Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia
in ACI rats," Molecular Carcinogenesis, vol.
According to the malignancy criteria adopted by Allen, Prasse and Mahaffey (11) the samples were classified into 3 groups: benign lesion (mammary hyperplasia
, benign epithelial tumor, benign mixed tumor), malignant (malignant epithelial tumor, malignant complex tumor, malignant mixed tumor) and inconclusive or insufficient (a smear with less than 5 cell groups, with each group containing 5 to 10 cells).
Later, Tavassoli et al (1) described similar inclusions in 2 cases of mammary hyperplasia
. These single-membrane-bound inclusions were characterized by one or more rounded bodies with a radiating corona of filaments.
Prolonged administrations of exogenous progestogens also seem to be associated with the development of pyometra (HEDLUND, 2005) and feline mammary hyperplasia
(NELSON & COUTO, 2001).