Mallory body

(redirected from Mallory hyaline)

Mallory body

[mal′ərē]
Etymology: Frank B. Mallory, American pathologist, 1862-1941; AS, bodig, body
an eosinophilic cytoplasmic inclusion, alcoholic hyalin, found in the liver cells. It is typically, but not always, associated with acute alcoholic liver injury. See also cirrhosis.

Mallory body

One or more aggregates of randomly oriented paranuclear eosinophilic microfilaments (which stain for cytokeratin, p62 and ubiquitin). While Mallory bodies are classically seen in alcoholic liver disease, especially if centrizonal, but may also occur in alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), primary biliary cirrhosis, primary sclerosing hepatitis, hepatitis C, Wilson’s disease, abetalipoproteinaemia, Indian childhood cirrhosis, intestinal bypass surgery for morbid obesity, corticosteroid therapy, amiodarone therapy, Weber-Christian disease, perhexiline maleate hepatitis, diethylaminoethoxyhexestrol-induced hepatitis, fatty liver in obesity, diabetes, idiopathic fatty liver, postintestinal resection, radiation pneumonitis, asbestosis, and idiopathic cirrhosis. They may also be seen in neoplasia: hepatocellular carcinoma, macro regenerative nodules, focal nodular hyperplasia and dysplastic nodules.

Mallory body

(mal′ŏ-rē) [G. Kenneth Mallory, U.S. pathologist, 1900–1986]
An inclusion body found in liver cells, especially in diseases caused by the excessive consumption of alcohol. Mallory bodies are composed of collections of intermediate filaments.
References in periodicals archive ?
The diagnosis of NAFLD was based on clinical history of nonalcoholism and established histologic features such as steatosis, lobular inflammation, Mallory hyaline, and hydropic change.
Presence of steatosis, fibrosis, inflammation, ballooning degeneration, and Mallory hyaline were recorded by 2 pathologists (D.
Hepatocellular carcinomas assigned as SH-HCC type showed steatohepatitic features in more than 5% of the tumor area (9) (including overall area in multiple HCCs), and displayed the combination of features described in steatohepatitis, including macrovesicular steatosis, ballooning degeneration, Mallory hyaline, fibrosis, and inflammation.
Among the 19 SH-HCC cases, all showed macrovesicular steatosis, inflammation and ballooning degeneration, with Mallory hyaline in 16 of 19 cases (84.
There were also transformations amongst the three stages or sub-types of active cell damage and cirrhosis, with or without Mallory hyaline, as well as inactive cirrhosis of the micro nodular cirrhosis (mnc) type.
The presence of Mallory hyaline appears to be a late phenomenon, accompanied by accumulation of not only the incriminated Cu, but the non-toxic Zn as well.
The more serious types 3 (fat accumulation and ballooning degeneration) and 4 (fat accumulation, ballooning degeneration, and either Mallory hyaline and/or fibrosis) are characterized as nonalcoholic steatohepatitis (NASH).
The 11 patients who were randomized to pioglitazone and vitamin E had a marked, significant improvement in three end-point measures: steatosis, ballooning, and Mallory hyaline, said Dr.