Much work has been done and debates about the malignant transformation
of SCAP are ongoing.
Although they are usually benign, some cases of malignant transformation
have been reported (3).
The frequency of MCT cases undergoing malignant transformation
ranges from 0.17% to 2%.
In collaboration with Beijing Stomatological Hospital affiliated with the Capital Medical University in China, Avalon and Genexosome Technologies have completed a clinical study and revealed miR185 as a novel saliva-based exosomal biomarker with strong correlation and predictive value for malignant transformation
from oral leukoplakia to oral cancer.
* Malignant transformation
in such a tumour is very rare, evidenced by regional or distant metastasis,  unusual finding (only 39 cases have been documented in the English language literature till date).
However, little is known about the involvement of HHS in the malignant transformation
FNAC was performed on the mass, which confirmed it to be PA with marked nuclear atypia suspicious for malignant transformation
(15) When histologic grades were combined into 2 groups, the malignant transformation
rate was higher in the severe dysplasia-CIS group (30.4%) than in the mild to moderate dysplasia group (10.6%).
is detected in 0.17-2% of MCTs.
is estimated to be 7%, and the recurrence is approximately 15% .
However, rare cases with adenomatous and even malignant transformation
have been reported.
Von Hippel-Lindau disease (VHL), also known as Familial cerebello retinal angiomatosis, is a rare genetic disorder characterised by visceral cysts and benign tumours with potential for subsequent malignant transformation