malignant neuroleptic syndrome
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malignant neuroleptic syndromeA life-threatening condition that affects < 1% of patients exposed to neuroleptics (e.g., phenothiazine, butyrophenones).
Fever, autonomic instability, muscle rigidity, tremor, cognitive changes, encephalopathy, delirium, and myoglobinuria, which start 1–3 days after beginning neuroleptic agents, including antipsychotics or antidepressants.
Increased CK, leukocytosis.
Stop drugs, antipyretics, cooling blankets, dantrolene, bromocriptine.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
malignant neuroleptic syndromeA complex that affects < 1% of Pts exposed to neuroleptics–phenothiazine, butyrophenones Clinical Onset 1-3 days after beginning antidepressant therapy, which causes hyperthermia, autonomic instability, muscle rigidity, myoglobinuria
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.