malate-aspartate shuttle

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Related to malate-aspartate shuttle: glycerophosphate shuttle, Glycerol phosphate shuttle

mal·ate-as·par·tate shut·tle

a mechanism for the transfer of NADH, reducing equivalents from the cytosol into the mitochondria using two isozymes of malate dehydrogenase and aspartate aminotransferase.


a salt of malic acid.

malate-aspartate shuttle
system for the transfer of reducing equivalents as NADH and H+ between the site of generation in glycolysis in the cytosol and the site of oxidation in the electron transport chain for production of ATP in the mitochondria. Reducing equivalents are transported into the mitochondria as malate, using oxaloacetate as the carbon carrier. The oxaloacetate is generated from transamination of aspartate. Oxaloacetate does not have a mitochondrial transport protein.
malate dehydrogenase, NAD-linked malate dehydrogenase
an enzyme found in the mitochondria (as part of the TCA cycle) or cytosol that participates in the reversible conversion of malate to oxaloacetate.
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