malate-aspartate shuttle

(redirected from Malate shuttle)

mal·ate-as·par·tate shut·tle

a mechanism for the transfer of NADH, reducing equivalents from the cytosol into the mitochondria using two isozymes of malate dehydrogenase and aspartate aminotransferase.
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Malate dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle (TCA), plays important metabolic roles in aerobic energy producing pathways and in malate shuttle (Figure 1) [5].