major depressive disorder


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Related to major depressive disorder: major depressive episode, generalized anxiety disorder

major depressive disorder

 
a mood disorder characterized by the occurrence of one or more major depressive epsiodes and the absence of any history of manic, mixed, or hypomanic episodes.

major depressive disorder

1. Synonym(s): major depression
2. a DSM diagnosis that is established when the specified criteria are met.

major depressive disorder

or

major depression

major depressive disorder

A chronic, relapsing illness affecting 3–6% of the population at a given time.
 
Lifetime risk
10–15%; it is linked to a high (10%–20%) rate of suicide, and high morbidity when compared with other medical illness.
 
Statistics
Taiwan, 1.5%; Korea, 3%; Puerto Rico, 4.3%; US, 5%; New Zealand, 12%; France, 16.4%; Lebanon, 19%.

Other findings
Positive dexamethasone test, sleep changes (e.g., decreased REM latency).

Major depressive disorder, five or more criteria
• Decreased appetite or loss of weight;
• Decreased concentration; 
• Decreased interest-in pleasurable activities;
• Dysphoric mood—sad, anxious, irritable; 
• Fatigue or decreased energy;
• Guilt or excessive self-blame;
• Psychomotor retardation or agitation;
• Sleep disturbances; 
• Suicidal ideation or suicidal attempt. 
 
DiffDx
AIDS, acute intermittent porphyria, amphetamine withdrawal, CA, endocrine disease (e.g., Addision’s disease, Cushing’s disease), hypothyroidism, infectious mononucleosis, influenza, malnutrition, multiple sclerosis, drugs (e.g., alpha-methyldopa, benzodiazepines, cimetidine, clonidine, corticosteroids, INH, OCs, propranolol, reserpine, thiazide diuretics).

major depressive disorder

Psychiatry A chronic, relapsing illness affecting 3–6% of the population at a given time Lifetime risk 10–15%; it is linked to a high–10% to 20% rate of suicide, and high morbidity when compared with other medical illness Statistics, Intl, low Taiwan 1.5%, Korea 3%, Puerto Rico 4.3%, US 5% High Lebanon 19%, France 16.4%, New Zealand 12% Other findings Positive dexamethasone test, sleep changes–eg, ↓ REM latency DiffDx AIDS, acute intermittent porphyria, amphetamine withdrawal, CA, endocrine disease–eg, Addision's disease, Cushing's disease, hypothyroidism, infectious mononucleosis, influenza, malnutrition, multiple sclerosis, drugs–eg, alpha-methyldopa, benzodiazepines, cimetidine, clonidine, corticosteroids, INH, OCs, propranolol, reserpine, thiazide diuretics
Major depressive disorder, 5 or more criteria
appetite or loss of weight
concentration
• Dysphoric mood Sad, anxious, irritable
• Fatigue or decreased energy
• Guilt or excessive self blame
interest in pleasurable activities
• Psychomotor retardation or agitation
• Sleep disturbances
• Suicidal ideation or suicidal attempt  AMN  16/9/96, p17

ma·jor de·pres·sion

, major depressive disorder (mājŏr dĕ-preshŭn, dĕ-presiv dis-ōrdĕr)
Mental illness characterized by sustained depression of mood, anhedonia, sleep and appetite disturbances, and feelings of worthlessness, guilt, and hopelessness. Also called clinical depression.

Major depressive disorder

A mood disorder characterized by profound feelings of sadness or despair.
Mentioned in: Conduct Disorder

ma·jor de·pres·sion

, major depressive disorder (mājŏr dĕ-preshŭn, dĕ-presiv dis-ōrdĕr)
Mental disorder characterized by sustained depression of mood, anhedonia, sleep and appetite disturbances, and feelings of worthlessness, guilt, and hopelessness.

Patient discussion about major depressive disorder

Q. What is MDD? I have heard this term on the radio referring to general depression, however I wanted to know what exactly is MDD.

A. A friend I made through this service refered me to the NIMH. They have a very nice website for the National Institute of Mental Health (NIMH) full of accurate descriptions of all the kinds of depression and other mental illnesses.

http://www.nimh.nih.gov/



Under their Health and Outreach tab at:
http://www.nimh.nih.gov/health/index.shtml

Click on Depression which brings you to
http://www.nimh.nih.gov/health/topics/depression/index.shtml

and keep reading


Major depressive disorder, also called major depression, is characterized by a combination of symptoms that interfere with a person's ability to work, sleep, study, eat, and enjoy once–pleasurable activities. Major depression is disabling and prevents a person from functioning normally. An episode of major depression may occur only once in a person's lifetime, but more often, it recurs throughout a person's life.

http://www.nimh.nih.gov/health/publications/depression/what-is-a-depressive-disorder.shtml

Q. I like to know the signs of serious major depression in women? I am lecturer in a college who is very approachable to students. If you take the top 10 lectures in the college the students will vote me first. Though I am proud of it I am not jealous. One of the clubs chose me as the best lecturer of the year and wanted me to send to another country for a special training in their own expense. Now I am here in this training which lasts for 6 more months. First week I fell home sick without seeing my students and got depressed and moreover I could not CONCENTRATE in the training and COULD NOT SLEEP. I like to know the signs of serious major depression in women?

A. If I wish if I am a student then I like to get trained under you. I am jealous of your students. The symptoms of depression in women are the same as those for major depression.
Common complaints include:
http://www.youtube.com/watch?v=iUTv_A2vUrI&eurl=http://www.imedix.com/health_community/viUTv%5EA2vUrI_final_stages_major_depression_can?q=major%20depression&feature=player_embedded
• Depressed mood Loss of interest or pleasure in activities you used to enjoy
• Feelings of guilt, hopelessness and worthlessness
• Suicidal thoughts or recurrent thoughts of death
• Sleep disturbance (sleeping more or sleeping less)
• Appetite and weight changes
• Difficulty concentrating
• Lack of energy and fatigue

More discussions about major depressive disorder
References in periodicals archive ?
An overview of selecting biomarker candidates for major depressive disorder. Front Psychiatry.
In Cox proportional hazards models with the baseline hazard function stratified by sex and age, [PM.sub.2.5] exposure indices were associated with an increased risk of major depressive disorder after adjusting for contextual and individual-level covariates.
Similarly, mean LDL-C and HDL-C concentrations were not significantly altered in patients of major depressive disorder when compared to the respective values in the controls11.
Screening for PTSD and major depressive disorder should be performed routinely in all rehabilitation programs and in all military facilities dedicated for veterans (14).
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
A total of 80 adult patients of ages between 18-60 years (44 female and 36 male) with diagnosed major depressive disorder were enrolled from out patient department (OPD) of psychiatry, Jinnah postgraduate Medical centre Karachi (JPMC), however only 74 patients remained till the completion of study.
Trivedi had reported from the Sequenced Treatment Alternatives to Relieve Depression trial (STAR*D), the largest study undertaken for major depressive disorder.
These results suggest a role for atypical antipsychotic agents in augmenting standard antidepressants for treatment-resistant major depressive disorder.
Result was consistent with the hypothesis that significant difference of mean IQ score was found between adults with Major Depressive Disorder and Schizophrenia (t=3.15, df =58, pandlt;.001).
for the treatment of major depressive disorder. This drug is a modified version of venlafaxine (Effexor XR), which belongs to a class of drugs known as serotonin norepinephrine reuptake inhibitors (SNRIs).
The symptoms of partial androgen deficiency in ageing men (PADAM) overlap considerably with those of major depressive disorder. Symptoms include a reduction in libido, lack of energy, decrease in strength and/or endurance, decreased enjoyment of life, feeling sad and/or grumpy, weak erections, reduced ability to work and play sports, and changes in sleep patterns.
Paroxetine was no more effective than a placebo in reducing the symptoms of major depressive disorder in a population that, for the first time, included patients younger than 12 years, reported Dr.

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