Optical coherence tomography is known to be effective for detecting early functional impairment in the magnocellular pathway (38).
The magnocellular pathway is one of the three pathways that go to the brain.
In recent years, dysfunctions in the magnocellular pathway have been investigated in schizophrenia.
The finding that impairment in magnocellular pathway is evident in depressive episode of bipolar disorder but not in unipolar depression may shed light on differences in pathogenesis of these disorders.
Considering the magnocellular pathway develops in the early gestational period, major depression may be caused by anomalies in later periods and psychosocial factors may have a critical role in depression.
Longitudinal studies with larger patient groups are required to investigate the changes in the magnocellular pathway in mental disorders.
(34) These frequency characteristics were believed to be specifically identified by the magnocellular pathway. (35)
More recent evidence suggests that the Goldmann size III stimulus used in SAP is actually superior to the FDT stimulus in preferentially stimulating the magnocellular pathway. (40) Furthermore, a histological study on monkeys indicated a shrinkage of retinal ganglion cells (before cell death), (41) which may help to explain the earlier observation of a preferential loss of larger optic nerve fibres in early glaucoma.