macrothrombocyte

A platelet that is larger than usual—e.g., the size of an RBC—a finding typical of Bernard-Soulier syndrome (BSS); up to 10% of normal platelets are ‘giant’—i.e., ‘squashed’ and oversized
DiffDx When > 20% of platelets are giant: idiopathic thromocytopaenic purpura (ITP), lymphoproliferative disorders, myeloproliferative disorders, reticulocytosis, disseminated intravascular coagulation (DIC), systemic lupus (SLE), grey platelet syndrome, May-Hegglin anomaly, type 2B von Willebrand’s disease, thrombotic thrombocytopaenic purpura (TTP)

macrothrombocyte

(măk″rō-thrŏm′bō-sīt) [″ + thrombos, clot, + kytos, cell]
A large platelet seen in some leukemias and rare disorders of platelets.
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References in periodicals archive ?
In the patient for whom pseudothrombocytopenia is considered, thrombocyte satellitosis and macrothrombocyte were not observed.
These particles include red cell fragments, microspherocytes, nucleated RBCs, nonlyzed RBCs, elliptocytosis, macrothrombocytes, platelet clumps, bacteria, parasitic organisms, and other interfering substances such as cryoglobulin, cold agglutinin, and macroglobinemia.
We excluded from the study, by examination for the blood smears, the pseudo-thrombopenic samples caused by platelet clumps, macrothrombocytes and platelet satellitism.
Diseases with increased MPV are characterized by macrothrombocytes among the hematological disorders and they can be seen during the course of idiopathic thrombocytopenic purpura (ITP), Bernard-Soulier syndrome, MayHegglin anomaly, preeclampsia, sepsis, and disseminated intravascular coagulation.
The slides were entirely scanned for platelet aggregates and/or macrothrombocytes and, if any, the samples were excluded from the study.