Immunohistochemical investigations for the expression of the proapoptotic protein (Bax) and the expression of macrosialin
cluster of differentiation (CD68).
Research suggests that macrophage uptake of oxLDL is regulated by cell surface atherogenic oxLDL receptors including class A macrophage scavenger receptors, class B type I scavenger receptors, macrosialin
(CD68) [1, 3].
, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli," Journal of Experimental Medicine, vol.
There are other receptors that have been reported to bind to oxLDL which include CD68 and its murine homolog macrosialin
, mucins, and LOX-1.
This receptor, also known as macrosialin
, is a member of the lysosomal-associated membrane protein (LAMP) family, which is expressed in macrophages, osteoclasts, dendritic cells, and microglia, where its principal role is to bind and uptake oxidized lipoproteins and apoptotic cells .
Microglia also express macrosialin
(CD68), a molecule involved in phagocytosis.
Glial activation was indicated by increased mRNA of the microglial markers CD14 (innate immune receptor) (Figure 3A) and CD68 (macrosialin
) (Figure 3B), and of astrocytic GFAP (Figure 3C).