gene mapping

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ge·net·ic map

an abstract representation of the ordered array of genetic loci such that the interval between entries has algebraic signs and magnitude proportional to the expected number of crossings over between them and distances are algebraically additive; for example, on a genetic map the combined distance between locus A and locus C is the algebraic sum of the two distances between loci A and B, and B and C.
Farlex Partner Medical Dictionary © Farlex 2012

gene mapping

Determining the location of hereditary information carried on chromosomes. In humans, this requires determining the base pairs (chemical code) of each of the estimated 20,000 to 25,000 genes. Once a gene is mapped, that information may be used to compare abnormal genes with normal ones. Molecular biological techniques may then be used to search for methods of treating and preventing conditions resulting from genetic abnormality.
Synonym: genome mapping; linkage map See: gene splicing
See also: mapping
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Macrorestriction analysis of genomic DNA (Pulsed field gel electrophoresis--PFGE).
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The preferred approach is genotyping (1), which is commonly performed by macrorestriction digestion of genomic DNA with a rare-cutting restriction endonuclease (2,3).
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aeruginosa isolates by pulsed-field gel electrophoresis (PFGE) following chromosomal macrorestriction has been shown to be epidemiologically useful for strain differentiation, [11-13] and this technique was employed to investigate P.
Pseudomonas aeruginosa bacteraemia in an academic hospital in South Africa
Pulsed-field gel electrophoresis (PFGE) was performed after macrorestriction with SmaI in a CHEF-DRIII system (Bio-Rad, USA), according to Saeedi et al., (12) and analyzed with Bionumerics v6.5 (Applied Maths, Belgium) using the unweighted pair-group method with the arithmetic mean (UPGMA) applying the Dice correlation coefficient.
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Macrorestriction polymorphism of genomic DNA determined by PFGE revealed the presence of two pulsotypes among the nine study isolates.
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Genotypic study documents divergence in the pathogenesis of bloodstream infection related central venous catheters in neonates

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