CLEC4E

(redirected from Macrophage-inducible C-type lectin)

CLEC4E

A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which acts as a cell surface receptor for an array of ligands, including damaged cells (e.g., SAP130, a nuclear protein released by dying cells), fungi (e.g., alpha-mannose residues on the genus Malassezia) and mycobacteria (e.g., trehalose 6,6’-dimycolate (TDM), a cell wall glycolipid). CLEC4E transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain (FCER1G) and
induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappaB.
References in periodicals archive ?
It has been reported that macrophage-inducible C-type lectin (Mincle) is activated by endogenous ligands secreted by dead adipocytes and drives ATM migration in the course of CLS organization [31].
Tsuda et al., "Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans," Diabetes, vol.
Suganami et al., "Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis," Nature Communications, vol.
Recently, the macrophage-inducible C-type lectin (Mincle) was also found to bind to mannan and Candida cells.
(2008) The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans.
CLRs family members include Dectin-1 (dendritic cell-associated C-type lectin-1), Dectin-2, macrophage-inducible C-type lectin (Mincle), the dendritic cell-specific ICAM3-grabbing nonintegrin (DC-SIGN), and DC NK lectin group receptor-1 (DNGR-1).
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