CCL22

(redirected from Macrophage-derived chemokine)

CCL22

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL22 binds CCR4 and is chemotactic for monocytes, dendritic cells, natural killer cells and activated T lymphocytes—but not for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also play a role in trafficking activated T lymphocytes to sites of inflammation.
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Stimulation of keratinocytes by TNF-[alpha] and IFN-[gamma] induces the expression of macrophage-derived chemokine (MDC), regulated on activation, normal T-cell expressed and secreted (RANTES), IL-8, and thymus and activation regulated chemokine (TARC) (Lim et al.
Abbreviations: SOL, Sanguisorba officinalis L.; ESOL, ethanol extract of SOL roots; MDC, macrophage-derived chemokine; TARC, thymus and activation regulated chemokine; RANTES, regulated on activation, normal T-cell expressed and secreted; STAT, signal transducer and activator of transcription; ERK, extracellular signal-regulated kinase; TNF-[alpha]/IFN-[gamma], tumor necrosis factor-[alpha]/interferon-[gamma].
So we investigated serum levels of macrophage-derived chemokine (MDC), and matrix metalloproteinase-9 (MMP-9), and to determine the relationship between serum levels and the disease activity of SLE.
Intercellular adhesion molecule-1 (ICAM-1), CC chemokines, macrophage-derived chemokine, E-select in and human leukocyte antigen DR (HLA-DR), over-expressed in VKC and acting concomitantly, may be responsible for the recruitment and activation of helper T cells in VKC.
Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.
Lucas et al., "Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
The levels of thymus- and activation-regulated chamomile (TARC/CCL17; R&D Systems), macrophage-derived chemokine (MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-[gamma] (Endogen), IL-4 (Amersham), IL-10 (Endogen), and IL-17 (R&D Systems) in the supernatants of BMDCs and T-cell cocultures or splenocyte cultures were measured by ELISA according to the manufacturers' instructions.
In a logistic regression model focusing on selected biomarkers, participants were more likely to have stage I cancer if they had higher levels of interleukin 2 (odds ratio, 51.4), interleukin 3 (OR, 11.0), and macrophage-derived chemokine (OR, 10.9).
In a logistic regression model that focused on selected biomarkers, participants were more likely to have stage I cancer if they had higher levels of inter-leukin 2 (odds ratio, 51.4), interleukin 3 (OR, 11.0), and macrophage-derived chemokine (OR, 10.9).
Stimulation with tumour necrosis factor-alpha (TNF-[alpha]) and interferon-gamma (IFN-[gamma] caused a significant increase in the production of the following chemokines: thymus- and activation- regulated chemokine (TARCJ/CCL17; macrophage-derived chemokine (MDQ/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTESJ/CCL5; and interleukin-8 (IL-8) in HaCaT cells.
Some of these were present in more than 3 samples: growth factors (fibroblast growth factor 4, placental growth factor), chemotactic factors [B lymphocyte chemoattractant/CXCL13, macrophage inflammatory protein (MIP)-1[beta]/CCL4, MIP-1[delta]/ CCL15, MIP-3[alpha]/CCL20, pulmonary and activation-related chemokine (PARC)/CCL18, leukemia inhibitory factor, oncostatin M], and antiinflammatory factors [tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, macrophage-derived chemokine (MDC)/CCL22].
However, IL-4 selectively induces eotaxin-2/CCL24, CCL18, and macrophage-derived chemokine (MDC/CCL22) in macrophages, and these effects are inhibited by IFN-[gamma].

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