CCL22

(redirected from Macrophage-derived chemokine)

CCL22

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL22 binds CCR4 and is chemotactic for monocytes, dendritic cells, natural killer cells and activated T lymphocytes—but not for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also play a role in trafficking activated T lymphocytes to sites of inflammation.
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Stimulation of keratinocytes by TNF-[alpha] and IFN-[gamma] induces the expression of macrophage-derived chemokine (MDC), regulated on activation, normal T-cell expressed and secreted (RANTES), IL-8, and thymus and activation regulated chemokine (TARC) (Lim et al.
Methyl 5-chloro-4,5-didehydrojasmonate Q7) inhibits macrophage-derived chemokine production via down-regulation of the signal transducers and activators of transcription 1 pathway in HaCaT human keratinocytes.
Ethanol extracts of Sanguisorba officinalis L. suppress TNF-[alpha]/IFN-[gamma]-induced pro-inflammatory chemokine production in HaCaT cells
So we investigated serum levels of macrophage-derived chemokine (MDC), and matrix metalloproteinase-9 (MMP-9), and to determine the relationship between serum levels and the disease activity of SLE.
KEY WORDS: Lupus erythematosus, Systemic, Macrophage-derived chemokine, Matrix metalloproteinase-9.
Serum levels of Mdc and MMP-9 and the relationship between serum levels and disease activity in the patients with systemic lupus erythematosus
Intercellular adhesion molecule-1 (ICAM-1), CC chemokines, macrophage-derived chemokine, E-select in and human leukocyte antigen DR (HLA-DR), over-expressed in VKC and acting concomitantly, may be responsible for the recruitment and activation of helper T cells in VKC.
Vernal keratoconjuctivitis: a review
Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.
Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells.
Genetic polymorphisms of CCL22 and CCR4 in patients with lung cancer
The levels of thymus- and activation-regulated chamomile (TARC/CCL17; R&D Systems), macrophage-derived chemokine (MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-[gamma] (Endogen), IL-4 (Amersham), IL-10 (Endogen), and IL-17 (R&D Systems) in the supernatants of BMDCs and T-cell cocultures or splenocyte cultures were measured by ELISA according to the manufacturers' instructions.
Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro
Among his accomplishments during the past 21 years were the cloning of the first hepatitis B surface antigen protein, interferon-gamma, multiple interferon-alpha genes, bacteriacidal permeability increasing protein, tumor necrosis factor-beta (TNF- beta), platelet activating factor acetylhydrolase, and macrophage-derived chemokine.
Patrick Gray Joins MacroGenics as Vice President, Research; Appointed to Lead Discovery Efforts at Seattle Site
Stimulation with tumour necrosis factor-alpha (TNF-[alpha]) and interferon-gamma (IFN-[gamma] caused a significant increase in the production of the following chemokines: thymus- and activation- regulated chemokine (TARCJ/CCL17; macrophage-derived chemokine (MDQ/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTESJ/CCL5; and interleukin-8 (IL-8) in HaCaT cells.
Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-[kappa]B in HaCaT cells
Some of these were present in more than 3 samples: growth factors (fibroblast growth factor 4, placental growth factor), chemotactic factors [B lymphocyte chemoattractant/CXCL13, macrophage inflammatory protein (MIP)-1[beta]/CCL4, MIP-1[delta]/ CCL15, MIP-3[alpha]/CCL20, pulmonary and activation-related chemokine (PARC)/CCL18, leukemia inhibitory factor, oncostatin M], and antiinflammatory factors [tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, macrophage-derived chemokine (MDC)/CCL22].
Cytokine profiling in human colostrum and milk by protein array
Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis.
Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in mice

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