Stimulation of keratinocytes by TNF-[alpha] and IFN-[gamma] induces the expression of macrophage-derived chemokine (MDC), regulated on activation, normal T-cell expressed and secreted (RANTES), IL-8, and thymus and activation regulated chemokine (TARC) (Lim et al.
Abbreviations: SOL, Sanguisorba officinalis L.; ESOL, ethanol extract of SOL roots; MDC, macrophage-derived chemokine; TARC, thymus and activation regulated chemokine; RANTES, regulated on activation, normal T-cell expressed and secreted; STAT, signal transducer and activator of transcription; ERK, extracellular signal-regulated kinase; TNF-[alpha]/IFN-[gamma], tumor necrosis factor-[alpha]/interferon-[gamma].
So we investigated serum levels of macrophage-derived chemokine
(MDC), and matrix metalloproteinase-9 (MMP-9), and to determine the relationship between serum levels and the disease activity of SLE.
Intercellular adhesion molecule-1 (ICAM-1), CC chemokines, macrophage-derived chemokine
, E-select in and human leukocyte antigen DR (HLA-DR), over-expressed in VKC and acting concomitantly, may be responsible for the recruitment and activation of helper T cells in VKC.
Human macrophage-derived chemokine
(MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.
Lucas et al., "Linked chromosome 16q13 chemokines, macrophage-derived chemokine
, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
The levels of thymus- and activation-regulated chamomile (TARC/CCL17; R&D Systems), macrophage-derived chemokine
(MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-[gamma] (Endogen), IL-4 (Amersham), IL-10 (Endogen), and IL-17 (R&D Systems) in the supernatants of BMDCs and T-cell cocultures or splenocyte cultures were measured by ELISA according to the manufacturers' instructions.
In a logistic regression model focusing on selected biomarkers, participants were more likely to have stage I cancer if they had higher levels of interleukin 2 (odds ratio, 51.4), interleukin 3 (OR, 11.0), and macrophage-derived chemokine
In a logistic regression model that focused on selected biomarkers, participants were more likely to have stage I cancer if they had higher levels of inter-leukin 2 (odds ratio, 51.4), interleukin 3 (OR, 11.0), and macrophage-derived chemokine
Stimulation with tumour necrosis factor-alpha (TNF-[alpha]) and interferon-gamma (IFN-[gamma] caused a significant increase in the production of the following chemokines: thymus- and activation- regulated chemokine (TARCJ/CCL17; macrophage-derived chemokine
(MDQ/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTESJ/CCL5; and interleukin-8 (IL-8) in HaCaT cells.
Some of these were present in more than 3 samples: growth factors (fibroblast growth factor 4, placental growth factor), chemotactic factors [B lymphocyte chemoattractant/CXCL13, macrophage inflammatory protein (MIP)-1[beta]/CCL4, MIP-1[delta]/ CCL15, MIP-3[alpha]/CCL20, pulmonary and activation-related chemokine (PARC)/CCL18, leukemia inhibitory factor, oncostatin M], and antiinflammatory factors [tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, macrophage-derived chemokine
However, IL-4 selectively induces eotaxin-2/CCL24, CCL18, and macrophage-derived chemokine
(MDC/CCL22) in macrophages, and these effects are inhibited by IFN-[gamma].