macrophage inflammatory protein

(redirected from Macrophage inflammatory proteins)

mac·ro·phage in·flam·ma·to·ry pro·tein (MIP),

a member of the chemokine family that is chemotactic for certain lymphocyte subsets such as T-cytotoxic cells.

macrophage inflammatory protein

Either of two chemokines—CCL3 (formerly MIP 1α) and CCL4 (formerly MIP 1β)—that are ligands for the CCR5 receptor. Both are produced by macrophages in response to bacterial endotoxins; activate granulocytes (neutrophils, eosinophils and basophils), leading to acute (neutrophilic) inflammation; and induce the synthesis and release of other pro-inflammatory cytokines (e.g., IL-1, IL-6 and TNFalpha) from fibroblasts and macrophages. CCL3 and CCL4 block the entry of M-tropic strains of HIV into various white cells.
References in periodicals archive ?
Macrophage inflammatory proteins: Biology and role in pulmonary inflammation.
The concentration of interleukin (IL)-1[sz], IL-6, IL-10, tumor necrosis factor-alpha (TNF-a), macrophage inflammatory protein (MIP)-1a, and MIP-2 in BALF was determined, and histopathological changes of the lung were observed.
The concentrations of interleukin (IL)-1[sz], IL-6, IL-10, tumor necrosis factor-alpha (TNF-a), macrophage inflammatory protein (MIP)-1a, and MIP-2 in BALF were determined using an enzyme-linked immunosorbent assay (ELISA) kit (RayBiotech Inc., Norcross, GA, USA) to assess pulmonary inflammation.
Expression of the Macrophage Inflammatory Proteins CCL3 and CXCL2 in Tissue of Patients with Infection and with Aseptic Loosening.
Preas II et al., "Detection of macrophage inflammatory protein (MIP)-1[alpha] and MIP-1[beta] during experimental endotoxemia and human sepsis," Journal of Infectious Diseases, vol.
Macrophage inflammatory proteins 1 and 2: expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung mineral dust exposure.

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