macrophage inflammatory protein

(redirected from Macrophage inflammatory cytokines)

mac·ro·phage in·flam·ma·to·ry pro·tein (MIP),

a member of the chemokine family that is chemotactic for certain lymphocyte subsets such as T-cytotoxic cells.
Farlex Partner Medical Dictionary © Farlex 2012

macrophage inflammatory protein

Either of two chemokines—CCL3 (formerly MIP 1α) and CCL4 (formerly MIP 1β)—that are ligands for the CCR5 receptor. Both are produced by macrophages in response to bacterial endotoxins; activate granulocytes (neutrophils, eosinophils and basophils), leading to acute (neutrophilic) inflammation; and induce the synthesis and release of other pro-inflammatory cytokines (e.g., IL-1, IL-6 and TNFalpha) from fibroblasts and macrophages. CCL3 and CCL4 block the entry of M-tropic strains of HIV into various white cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production.

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