macrophage activating factor
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Related to macrophage activating factor: migration inhibitory factor
macrophage activating factor (MAF)
Etymology: Gk. makros, large, phagein, to eat; L, activus, active, facere, to make
a lymphokine released from a sensitized leukocyte that induces changes in the appearance and function of macrophages and makes them active against certain antigens.
macrophage activating factorAny of a heterogeneous group of lymphokines secreted by sensitised lymphocytes, the most potent of which is IFN-gamma. IFN-activated macrophages have increased bactericidal and tumouricidal activity and morphological evidence of “maturation”—e.g., increased spreading, pseudopod formation and vacuolisation.
macrophage activating factorAbbreviation: MAF
A lymphokine that stimulates macrophages to become more effective killers of certain microbial cells. Macrophages stimulated by MAF can kill tumor cells.
See also: factor