Gastrointestinal disturbances, hepatic damages are the common side effects of macrolide
resistance in Mycoplasma pneumoniae, Israel, 2010.
pneumoniae and fewer contraindications, macrolides
have been the first choice for the clinical treatment of MPP (18,19).
- Watertown, Massachusetts-based antibiotic developer Macrolide
Pharmaceuticals has been granted a CARB-X award of up to USD 6.8m to support the development of a novel fully synthetic, orally available macrolide
antibiotic with Gram-negative activity, with the aim of treating serious infections including drug-resistant complicated urinary tract infections, the company said.
Fluoroquinolones or macrolides
alone versus combined with B-lactams for adults with community-acquired pneumonia: systematic review and meta-analysis.
The aim of this study was to determine the presence of several VFs and the levels and molecular mechanisms of resistance to quinolones and macrolides
in a series of Campylobacter spp.
Despite this fact, physician adherence to guideline-concordant antibiotic therapy remained infrequent as clinicians continued to use macrolides
, especially azithromycin, as CAP monotherapy .
 57 Undetermined Yes Reference Antimicrobial class (quinolone, Outcome macrolide
, or both quinolone and macrolide
) Koufakis et al.
this gene is responsible for an efflux mechanism which confers resistance to macrolides
and type B streptogramins, but not to clindamycin.
are antibacterial agents frequently used for the treatment of respiratory tract infections in children.
Current guidelines recommend the latter two approaches, which has caused a widespread increase in the use of macrolides
and fluoroquinolones--and in turn has increased antibiotic resistance.
Labro, "Anti-inflammatory activity of macrolides
: a new therapeutic potential?" Journal of Antimicrobial Chemotherapy, vol.